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Preliminary μSR studies on the incorporation of steroidal drug molecules into liposomes

Barker, S.A., Cottrell, S.P., Giblin, S.R., Jayasooriya, U.A. (2006) Preliminary μSR studies on the incorporation of steroidal drug molecules into liposomes. Physica B: Condensed Matter, 374-37 . pp. 332-335. ISSN 0921-4526. (doi:10.1016/j.physb.2005.11.089) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:78863)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://doi.org/10.1016/j.physb.2005.11.089

Abstract

Muon spin relaxation of two liposome samples consisting of 100% DPPC (dipalmitoylphosphatidylcholine) and 50:50 mole% DPPC:Cholesterol at a final lipid concentration of 100 mg/mL are compared. The observation of a significant loss in the muonium fraction from 11% to 6% when cholesterol is present is compatible with radical formation in the second sample. Also reported are measurements on pure solid cholesterol where a clear T1 minimum at ca 100 K, corresponding to a dynamic process with activation energy of ca. 1.89 kJ mol-1 and an attempt frequency of 5.89×1010 s-1, is observed. An estimate of a hyperfine interaction of 255.4 MHz for this radical predicts a ΔM=1 ALC transition at 0.94 T

Item Type: Article
DOI/Identification number: 10.1016/j.physb.2005.11.089
Uncontrolled keywords: Drug delivery, Liposomes, Spin resonance, Steroids, Activation energy, Concentration (process), Drug products, Elementary particles, Free radicals, Drug delivery, Liposomes, Spin resonance, Steroids, Relaxation processes
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Susan Barker
Date Deposited: 27 Nov 2019 12:33 UTC
Last Modified: 27 Nov 2019 12:33 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/78863 (The current URI for this page, for reference purposes)
Barker, S.A.: https://orcid.org/0000-0003-4880-0253
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