Skip to main content
Kent Academic Repository

A laser imaging and neutron reflection investigation into the monolayer behaviour of fatty acids used for taste masking microspheres

Qi, S., Roser, S.J., Deutsch, D., Barker, S.A., Craig, D.Q.M. (2008) A laser imaging and neutron reflection investigation into the monolayer behaviour of fatty acids used for taste masking microspheres. Journal of Pharmaceutical Sciences, 97 (5). pp. 1864-1877. ISSN 0022-3549. (doi:10.1002/jps.21100) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:78860)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
https://doi.org/10.1002/jps.21100

Abstract

Fatty acid microspheres have been used for taste masking purposes whereby the drug is preferentially released in the lower gastrointestinal tract, although the mechanisms involved are poorly understood. In this study, we use a combination of surface pressure measurements, Brewster angle microscopy (BAM) and neutron reflectivity measurements to study the phase miscibility and escaping tendency from mixed stearic and palmitic acid films with a view to relating this to drug dissolution behaviour. It was noted that mixed systems showed considerably greater film interaction and instability than those composed of the pure lipid, especially in alkaline media. BAM studies were able to identify a range of phase separated structures for both the pure and mixed systems. Neutron reflectivity studies indicated a marked selective dissolution of palmitic acid into the subphase as a function of time and allowed quantification of the rate of dissolution of this species. It is concluded that the fatty acids are interacting within the monolayer and in addition the palmitic acid is escaping the mixed monolayers and dissolving into the alkali subphase. These findings have strong relevance for understanding the mechanism of drug release from the associated microspheres.

Item Type: Article
DOI/Identification number: 10.1002/jps.21100
Uncontrolled keywords: Imaging methods, Light-scattering, Lipids, Microspheres, Monolayer, fatty acid, microsphere, palmitic acid, stearic acid, microsphere, alkalinity, article, Brewster angle microscopy, drug formulation, drug release, drug solubility, image analysis, intestine absorption, laser, light scattering, miscibility, monolayer culture, neutron activation analysis, phase separation, taste, chemistry, laser, microscopy, neutron, pH, taste, Fatty Acids, Hydrogen-Ion Concentration, Lasers, Microscopy, Microspheres, Neutrons, Taste
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Susan Barker
Date Deposited: 27 Nov 2019 12:06 UTC
Last Modified: 16 Nov 2021 10:26 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/78860 (The current URI for this page, for reference purposes)

University of Kent Author Information

  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.