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An investigation into water interactions with amorphous and milled salbutamol sulphate: The development of predictive models for uptake and recrystallization

Grisedale, L.C., Belton, P.S., Jamieson, M.J., Barker, S.A., Craig, D.Q.M. (2012) An investigation into water interactions with amorphous and milled salbutamol sulphate: The development of predictive models for uptake and recrystallization. International Journal of Pharmaceutics, 422 (1-2). pp. 220-228. ISSN 0378-5173. (doi:10.1016/j.ijpharm.2011.10.055) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:78848)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://doi.org/10.1016/j.ijpharm.2011.10.055

Abstract

An investigation into the effect of water uptake on the glass transition of spray dried and milled salbutamol sulphate has been performed, with a particular view to exploring how the water uptake, T g value and recrystallization behaviour correlate. Samples of milled and spray dried drug were stored under controlled humidity conditions and the T g measured as a function of time. The T g was measured using modulated temperature differential scanning calorimetry (MTDSC) while the water content was measured using thermogravimetric analysis (TGA). A correlation was found between time of storage, water content and T g in that the samples showed time dependent equilibration with the storage environment (either gaining or losing water depending on the RH). The relationship between water content and stability, based on the concept of T g lowering, was modelled using the semi-empirical approach of Royall et al. (1999) as well as a derivation of the Kwei equation which allowed the interaction between the water and substrate to be accounted for. A method for predicting stability based on two simple DSC runs is proposed. In addition, we discuss the observation of a double glass transition for the spray dried samples.

Item Type: Article
DOI/Identification number: 10.1016/j.ijpharm.2011.10.055
Uncontrolled keywords: Calorimetry, Crystallization, Glass transition, Plasticizer, Salbutamol sulphate, Thermal analysis, salbutamol sulfate, article, crystallization, differential scanning calorimetry, drug formulation, drug stability, drug storage, environmental factor, glass transition temperature, molecular dynamics, priority journal, process model, water transport, Albuterol, Bronchodilator Agents, Calorimetry, Differential Scanning, Chemistry, Pharmaceutical, Crystallization, Desiccation, Drug Stability, Drug Storage, Humidity, Microscopy, Electron, Scanning, Models, Chemical, Spectroscopy, Fourier Transform Infrared, Surface Properties, Technology, Pharmaceutical, Thermogravimetry, Time Factors, Transition Temperature, Water
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Susan Barker
Date Deposited: 27 Nov 2019 10:04 UTC
Last Modified: 27 Nov 2019 10:04 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/78848 (The current URI for this page, for reference purposes)
Barker, S.A.: https://orcid.org/0000-0003-4880-0253
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