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Development of photothermal FTIR microspectroscopy as a novel means of spatially identifying amorphous and crystalline salbutamol sulfate on composite surfaces

Grisedale, L.C., Moffat, J.G., Jamieson, M.J., Belton, P.S., Barker, S.A., Craig, D.Q.M. (2013) Development of photothermal FTIR microspectroscopy as a novel means of spatially identifying amorphous and crystalline salbutamol sulfate on composite surfaces. Molecular Pharmaceutics, 10 (5). pp. 1815-1823. ISSN 1543-8384. (doi:10.1021/mp300605s) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:78845)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://doi.org/10.1021/mp300605s

Abstract

Photothermal Fourier transform infrared (FTIR) microspectroscopy (PTMS), involving the combination of FTIR spectroscopy with atomic force microscopy, has been used to examine compacts of amorphous and crystalline salbutamol sulfate in order to assess the ability of the technique to distinguish between different physical forms in a multicomponent material. Samples of amorphous and crystalline material were assessed using modulated temperature differential scanning calorimetry (DSC), atomic force microscopy, microthermal analysis, and conventional FTIR. Mixed compacts were then prepared such that verification of the location of the forms present was possible via topography and localized thermal analysis. PTMS studies were then performed on selected interrogation points, with spectra obtained which were largely intermediate between those corresponding to the two individual forms. Calculation of the thermal diffusivity indicated a resolution for the technique corresponding to a hemisphere of a major diameter in the region of 40 μm, which is large in relation to the particle sizes involved. However, distinction into amorphous, crystalline, and indeterminate categories was possible using chemometric analysis (hierarchical cluster analysis and principal component analysis). Good agreement was found between the identification methods for the mixed systems. The study has therefore shown the potential, as well as identifying the limitations, of using PTMS as a means of spatially identifying components in complex materials.

Item Type: Article
DOI/Identification number: 10.1021/mp300605s
Uncontrolled keywords: amorphous, chemometrics, local thermal analysis, photothermal microspectroscopy, salbutamol sulfate, salbutamol sulfate, beta 2 adrenergic receptor stimulating agent, salbutamol, article, atomic force microscopy, chemometric analysis, cluster analysis, crystal structure, differential scanning calorimetry, infrared spectroscopy, microthermal analysis, outcome assessment, particle size, photothermal fourier transform infrared microspectroscopy, priority journal, spectrometer, thermal analysis, topography, atomic force microscopy, chemistry, crystallization, heat, infrared spectroscopy, medicinal chemistry, physical chemistry, procedures, surface property, thermal conductivity, Adrenergic beta-2 Receptor Agonists, Albuterol, Chemistry, Pharmaceutical, Crystallization, Hot Temperature, Microscopy, Atomic Force, Physicochemical Phenomena, Spectroscopy, Fourier Transform Infrared, Surface Properties, Thermal Conductivity
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Susan Barker
Date Deposited: 27 Nov 2019 09:38 UTC
Last Modified: 27 Nov 2019 09:38 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/78845 (The current URI for this page, for reference purposes)
Barker, S.A.: https://orcid.org/0000-0003-4880-0253
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