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Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels

Alharbi, Naif Khalaf, Qasim, Ibrahim, Almasoud, Abdulrahman, Aljami, Haya A, Alenazi, Mohamed W, Alhafufi, Ali, Aldibasi, Omar S, Hashem, Anwar M, Kasem, Samy, Albrahim, Raed, and others. (2019) Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels. Scientific Reports, 9 (1). Article Number 16292. ISSN 2045-2322. (doi:10.1038/s41598-019-52730-4) (KAR id:78517)

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https://doi.org/10.1038/s41598-019-52730-4

Abstract

MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups receiving control vaccinations. Infectious camels with active naturally acquired MERS-CoV infection, were co-housed with the vaccinated camels at a ratio of 1:2 (infected:vaccinated); nasal discharge and virus titres were monitored for 14 days. Overall, the vaccination reduced virus shedding and nasal discharge (p = 0.0059 and p = 0.0274, respectively). Antibody responses in seropositive camels were enhancedby the vaccine; these camels had a higher average age than seronegative. Older seronegative camels responded more strongly to vaccination than younger animals; and neutralising antibodies were detected in nasal swabs. Further work is required to optimise vaccine regimens for younger seronegative camels.

Item Type: Article
DOI/Identification number: 10.1038/s41598-019-52730-4
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Nigel Temperton
Date Deposited: 11 Nov 2019 10:46 UTC
Last Modified: 19 Oct 2020 14:23 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/78517 (The current URI for this page, for reference purposes)
Temperton, Nigel J.: https://orcid.org/0000-0002-7978-3815
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