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Sequence Isomerism in Uniform Polyphosphoesters Programmes Self-Assembly and Folding

Appukutti, Nadeema and Serpell, Christopher J. (2019) Sequence Isomerism in Uniform Polyphosphoesters Programmes Self-Assembly and Folding. Working paper. ChemRxiv 10.26434/chemrxiv.7666316.v1. (doi:10.26434/chemrxiv.7666316.v1)

Abstract

Non-natural sequence-defined polymers have the potential to recapitulate the unique structures and functions of proteins. To achieve this goal requires not only high-efficiency synthesis platforms, but also an understanding of the relationship between sequence and folding/self-assembly. In a step towards that goal, we have here exploited the high-yielding solid phase phosphoramidite synthesis commonly used to make DNA, and generated two sequence-isomeric polymers which display sequence-programmed folding and self-assembly. These findings open up possibilities for more sophisticated sequence/structure relationships using the same synthetic platform.

Item Type: Monograph (Working paper)
DOI/Identification number: 10.26434/chemrxiv.7666316.v1
Subjects: Q Science > QD Chemistry
Divisions: Faculties > Sciences > School of Physical Sciences
Depositing User: Christopher Serpell
Date Deposited: 07 Nov 2019 14:28 UTC
Last Modified: 08 Nov 2019 15:08 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/78376 (The current URI for this page, for reference purposes)
Serpell, Christopher J.: https://orcid.org/0000-0002-2848-9077
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