Thomas, Samuel, Balónová, Barbora, Cinatl, Jindrich, Wass, Mark N., Serpell, Christopher J., Blight, Barry A., Michaelis, Martin (2020) Thiourea and Guanidine Compounds and their Iridium Complexes in Drug-Resistant Cancer Cell Lines: Structure-Activity Relationships and Direct Luminescent Imaging. ChemMedChem, 15 (4). pp. 349-353. ISSN 1860-7179. (doi:10.1002/cmdc.201900591) (KAR id:78375)
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Official URL https://doi.org/10.1002/cmdc.201900591 |
Abstract
Thiourea and guanidine units are found in nature, medicine, and materials. Their continued exploration in applications as diverse as cancer therapy, sensors, and electronics means that their toxicity is an important consideration. We have systematically synthesised a set of thiourea compounds and their guanidine analogues, and elucidated structure-activity relationships in terms of cellular toxicity in three ovarian cancer cell lines and their cisplatin-resistant sub-lines. We have been able to use the intrinsic luminescence of iridium complexes to visualise the effect of both structure alteration and cellular resistance mechanisms. These findings provide starting points for the development of new drugs and consideration of safety issues for novel thiourea- and guanidine-based materials.
Item Type: | Article |
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DOI/Identification number: | 10.1002/cmdc.201900591 |
Subjects: | Q Science > QD Chemistry |
Divisions: |
Divisions > Division of Natural Sciences > School of Biosciences Divisions > Division of Natural Sciences > School of Physical Sciences |
Depositing User: | Christopher Serpell |
Date Deposited: | 07 Nov 2019 14:20 UTC |
Last Modified: | 16 Feb 2021 14:09 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/78375 (The current URI for this page, for reference purposes) |
Wass, Mark N.: | ![]() |
Serpell, Christopher J.: | ![]() |
Blight, Barry A.: | ![]() |
Michaelis, Martin: | ![]() |
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