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Thiourea and Guanidine Compounds and their Iridium Complexes in Drug-Resistant Cancer Cell Lines: Structure-Activity Relationships and Direct Luminescent Imaging

Thomas, Samuel, Balónová, Barbora, Cinatl, Jindrich, Wass, Mark N., Serpell, Christopher J., Blight, Barry A., Michaelis, Martin (2020) Thiourea and Guanidine Compounds and their Iridium Complexes in Drug-Resistant Cancer Cell Lines: Structure-Activity Relationships and Direct Luminescent Imaging. ChemMedChem, 15 (4). pp. 349-353. ISSN 1860-7179. (doi:10.1002/cmdc.201900591) (KAR id:78375)

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Abstract

Thiourea and guanidine units are found in nature, medicine, and materials. Their continued exploration in applications as diverse as cancer therapy, sensors, and electronics means that their toxicity is an important consideration. We have systematically synthesised a set of thiourea compounds and their guanidine analogues, and elucidated structure-activity relationships in terms of cellular toxicity in three ovarian cancer cell lines and their cisplatin-resistant sub-lines. We have been able to use the intrinsic luminescence of iridium complexes to visualise the effect of both structure alteration and cellular resistance mechanisms. These findings provide starting points for the development of new drugs and consideration of safety issues for novel thiourea- and guanidine-based materials.

Item Type: Article
DOI/Identification number: 10.1002/cmdc.201900591
Subjects: Q Science > QD Chemistry
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Divisions > Division of Natural Sciences > School of Physical Sciences
Depositing User: Christopher Serpell
Date Deposited: 07 Nov 2019 14:20 UTC
Last Modified: 16 Feb 2021 14:09 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/78375 (The current URI for this page, for reference purposes)
Wass, Mark N.: https://orcid.org/0000-0001-5428-6479
Serpell, Christopher J.: https://orcid.org/0000-0002-2848-9077
Blight, Barry A.: https://orcid.org/0000-0003-1166-6206
Michaelis, Martin: https://orcid.org/0000-0002-5710-5888
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