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Cell biology of human vascular smooth muscle

Chan, P. (1994) Cell biology of human vascular smooth muscle. Annals of the Royal College of Surgeons of England, 76 (5). pp. 298-303. ISSN 0035-8843. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:78369)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC25024...

Abstract

Vascular smooth muscle is the cellular substrate of most significant arterial diseases. Restenosis after angioplasty and surgery mainly represents vascular smooth muscle reaction to trauma, a process which is also significant in the early stages of atherogenesis. Empirical approaches, based on findings in animal models of vascular injury, have notably failed to make any impact on human restenosis. We have developed and validated growth of the human VSMC in culture as a model of restenosis. Intimal hyperplastic lesions producing vascular restenosis contain cells that have reduced sensitivity to physiological growth inhibition by heparin in cell culture conditions, compared with cells from normal vascular tissue. Undiseased saphenous vein obtained from patients with intimal hyperplastic restenoses also contain cells that are relatively resistant to heparin inhibition. Arterial healing that progresses to restenosis may have distinct and fundamental differences at the cellular level from the normal process of arterial healing after injury.

Item Type: Article
Uncontrolled keywords: Arterial Occlusive Diseases/*pathology, Cell Division, Cells, Cultured, Drug Resistance/physiology, Heparin/pharmacology, Humans, Muscle, Smooth, Vascular/cytology/drug effects/*pathology, Recurrence, *Vascular Surgical Procedures
Divisions: Divisions > Division of Natural Sciences > Kent and Medway Medical School
Depositing User: Philip Chan
Date Deposited: 08 Nov 2019 10:18 UTC
Last Modified: 25 Nov 2021 16:41 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/78369 (The current URI for this page, for reference purposes)
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