Chan, P., Patel, M., Betteridge, L., Munro, E., Schachter, M., Sever, P., Chan, P., Munro, E., Wolfe, J. (1993) Abnormal growth regulation of vascular smooth muscle cells by heparin in patients with restenosis. The Lancet, 341 (8841). pp. 341-342. ISSN 0140-6736. (doi:10.1016/0140-6736(93)90139-8) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:78356)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: https://doi.org/10.1016/0140-6736(93)90139-8 |
Abstract
Proliferation of vascular smooth muscle cells (VSMC) underlies myointimal hyperplasia, which can lead to restenosis after angioplasty and vascular surgery. We propose that some individuals have an intrinsic capacity for this exaggerated response to vascular injury, partly through decreased sensitivity to the physiological growth inhibitor heparin. We investigated the effect of heparin on VSMC from restenotic lesions and from apparently normal vessels of the same patients, and VSMC from control patients undergoing primary bypass procedures. Cells from patients with restenosis (both restenotic lesion and undiseased vein) showed much lower sensitivity to growth inhibition by heparin than the controls (median inhibition 8 [95% CI -2 to 25] vs 22 [15-44]%, p<0·001); this finding suggests aberrant growth regulation in these cells.
| Item Type: | Article |
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| DOI/Identification number: | 10.1016/0140-6736(93)90139-8 |
| Uncontrolled keywords: | heparin, adult, article, blood vessel occlusion, clinical article, controlled study, growth regulation, human, hyperplasia, priority journal, vascular smooth muscle, vascular surgery, Arterial Occlusive Diseases, Cell Division, Cells, Cultured, Constriction, Pathologic, Heparin, Human, Muscle, Smooth, Vascular, Recurrence, Support, Non-U.S. Gov't |
| Divisions: | Divisions > Division of Natural Sciences > Kent and Medway Medical School |
| Depositing User: | Philip Chan |
| Date Deposited: | 08 Nov 2019 09:37 UTC |
| Last Modified: | 14 Dec 2023 04:15 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/78356 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Chan, P..
| Creator's ORCID: |
 https://orcid.org/0000-0001-9780-140X
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