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Sterol Uptake by an Alkali-β-Cyclodextrin Metal–Organic Framework

Blight, Barry A., Ahmad, Towseef I., Shepherd, Helena J., Jennings, Christopher S., Ferland, Livia I., Teat, Simon J., Rossman, Jeremy S. (2019) Sterol Uptake by an Alkali-β-Cyclodextrin Metal–Organic Framework. Crystal Growth and Design, 20 (1). pp. 43-48. ISSN 1528-7483. (doi:10.1021/acs.cgd.9b01457) (KAR id:78268)

Abstract

β-Cyclodextrin is well-known in cellular biology for its ability to moderate cholesterol levels in lipid bilayer membranes. Its use in extended network solids remains elusive due to the low symmetry of this macrocyclic system. Self-assembly of two different β-cyclodextrin metal–organic frameworks (MOFs) with extended nanotube structures is achieved by crystallization with excess potassium hydroxide, one in the presence of cholesterol. We then further demonstrate the proclivity of one of these MOFs to absorb cholesterol and two other sterols from solution using NMR and confocal microscopy techniques. This work demonstrates that these network solids show great potential in both substrate delivery and/or extraction.

Item Type: Article
DOI/Identification number: 10.1021/acs.cgd.9b01457
Uncontrolled keywords: coordination networks, metal-organic frameworks, cyclodextrin, cholesterol, organic molecule absorption
Subjects: Q Science > QD Chemistry
Divisions: Divisions > Division of Natural Sciences > Physics and Astronomy
Depositing User: Helena Shepherd
Date Deposited: 05 Nov 2019 14:59 UTC
Last Modified: 09 Dec 2022 06:20 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/78268 (The current URI for this page, for reference purposes)

University of Kent Author Information

Blight, Barry A..

Creator's ORCID: https://orcid.org/0000-0003-1166-6206
CReDIT Contributor Roles:

Ahmad, Towseef I..

Creator's ORCID:
CReDIT Contributor Roles:

Shepherd, Helena J..

Creator's ORCID: https://orcid.org/0000-0003-0832-4475
CReDIT Contributor Roles:

Rossman, Jeremy S..

Creator's ORCID: https://orcid.org/0000-0001-6124-4103
CReDIT Contributor Roles:
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