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Sterol Uptake by an Alkali-β-Cyclodextrin Metal–Organic Framework

Blight, Barry A., Ahmad, Towseef I., Shepherd, Helena J., Jennings, Christopher S., Ferland, Livia I., Teat, Simon J., Rossman, Jeremy S. (2019) Sterol Uptake by an Alkali-β-Cyclodextrin Metal–Organic Framework. Crystal Growth and Design, 20 (1). pp. 43-48. ISSN 1528-7483. (doi:10.1021/acs.cgd.9b01457) (KAR id:78268)

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https://doi.org/10.1021/acs.cgd.9b01457

Abstract

β-Cyclodextrin is well-known in cellular biology for its ability to moderate cholesterol levels in lipid bilayer membranes. Its use in extended network solids remains elusive due to the low symmetry of this macrocyclic system. Self-assembly of two different β-cyclodextrin metal–organic frameworks (MOFs) with extended nanotube structures is achieved by crystallization with excess potassium hydroxide, one in the presence of cholesterol. We then further demonstrate the proclivity of one of these MOFs to absorb cholesterol and two other sterols from solution using NMR and confocal microscopy techniques. This work demonstrates that these network solids show great potential in both substrate delivery and/or extraction.

Item Type: Article
DOI/Identification number: 10.1021/acs.cgd.9b01457
Uncontrolled keywords: coordination networks, metal-organic frameworks, cyclodextrin, cholesterol, organic molecule absorption
Subjects: Q Science > QD Chemistry
Divisions: Faculties > Sciences > School of Physical Sciences
Depositing User: Helena Shepherd
Date Deposited: 05 Nov 2019 14:59 UTC
Last Modified: 12 Feb 2020 16:14 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/78268 (The current URI for this page, for reference purposes)
Blight, Barry A.: https://orcid.org/0000-0003-1166-6206
Shepherd, Helena J.: https://orcid.org/0000-0003-0832-4475
Teat, Simon J.: https://orcid.org/0000-0001-9515-2602
Rossman, Jeremy S.: https://orcid.org/0000-0001-6124-4103
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