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The influence of drug solubility and sampling frequency on metformin and glibenclamide release from double-layered particles: experimental analysis and mathematical modelling

Shams, T., Brako, F., Huo, S., Harker, A.H., Edirisinghe, U., Edirisinghe, M. (2019) The influence of drug solubility and sampling frequency on metformin and glibenclamide release from double-layered particles: experimental analysis and mathematical modelling. Journal of The Royal Society Interface, 16 (155). ISSN 1742-5689. E-ISSN 1742-5662. (doi:10.1098/rsif.2019.0237) (KAR id:78241)

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https://dx.doi.org/10.1098/rsif.2019.0237

Abstract

Co-axial electrohydrodynamic atomization was used to prepare core/shell polymethylsilsesquioxane particles for co-delivery of metformin and glibenclamide in a sustained release manner. The drug-loaded microparticles were mostly spherical and uniformly distributed in size, with average diameters between 3 and 5 µm across various batches. FTIR was used to confirm the presence of drugs within the particles while X-ray diffraction studies revealed drugs encapsulated existed predominantly in the amorphous state. Intended as systems that potentially can act as depot formulations for long-term release of antidiabetics, a detailed analysis of drug release from these particles was necessary. Drugs of different solubilities were selected in order to study the effects of drug solubility from a core/shell particle system. Further analyses to determine how conditions such as release into a limited volume of media, sampling rate and partitioning of drug between the core and shell layers influenced drug release were conducted by comparing experimental and mathematically modelled outcomes. It was found that while the solubility of drug may affect release from such systems, rate of removal of drug (sampling frequency) which upsets local equilibrium at the particle/solution interface prompting a rapid release to redress the equilibrium influenced release more.

Item Type: Article
DOI/Identification number: 10.1098/rsif.2019.0237
Uncontrolled keywords: depot formulations; electrospraying; diabetes mellitus; metformin; glibenclamide; biomaterials
Subjects: R Medicine
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Francis Brako
Date Deposited: 04 Nov 2019 15:00 UTC
Last Modified: 15 Sep 2020 12:34 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/78241 (The current URI for this page, for reference purposes)
Brako, F.: https://orcid.org/0000-0002-1163-1874
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