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Chronic exposure to outdoor air pollution and markers of systemic inflammation

Forbes, Lindsay, Patel, Minal, Rudnicka, Alicja, Cook, Derek, Bush, Tony, Stedman, John, Whincup, Peter, Strachan, David, Anderson, Ross (2009) Chronic exposure to outdoor air pollution and markers of systemic inflammation. Epidemiology, 20 (2). pp. 245-253. ISSN 1044-3983. E-ISSN 1531-5487. (doi:10.1097/EDE.0b013e318190ea3f) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1097/EDE.0b013e318190ea3f

Abstract

Background: Cohort studies suggest that long-term exposure to higher levels of outdoor air pollution increases risk of developing cardiovascular disease. One suggested mechanism is that air pollution, especially particulate matter, induces systemic inflammation, thereby increasing the risk of developing long-term pathologic changes in the cardiovascular system, We aimed to examine the association between long-term exposure to higher levels of air pollution and chronic systemic inflammation.

Methods: We examined the relationship between 2 markers of systemic inflammation (fibrinogen and C-reactive protein) and measures of outdoor air pollution estimated for each postcode sector of residence, using models incorporating information on pollutant emissions from multiple sources, and atmospheric dispersion and processing, in 3 representative cross-sectional studies of the English population in 1994, 1998, and 2003. These included about 25,000 adults with fibrinogen measurements and 17,000 adults with C-reactive protein measurements. We used multilevel linear regression modeling and pooled the results from the 3 surveys using meta-analysis.

Results: We found no associations between concentrations of fibrinogen or C-reactive protein and measures of outdoor air pollution (particulate matter <10 μm in diameter (PM10), nitrogen dioxide, sulfur dioxide, and ozone). Specifically, we found, for each 1-μg/m3 increase in PM10 concentration, a change in fibrinogen concentrations of −0.08% (95% confidence interval = 0.25–0.10) and in C-reactive protein concentrations of 0.14% (95% confidence interval = 1.00–1.30).

Conclusions: Our findings do not support the hypothesis that the association between outdoor air pollution exposure and later cardiovascular disease is mediated by chronic systemic inflammation.

Item Type: Article
DOI/Identification number: 10.1097/EDE.0b013e318190ea3f
Additional information: Unmapped bibliographic data: DB - Scopus [Field not mapped to EPrints] M3 - Article [Field not mapped to EPrints]
Subjects: R Medicine
Divisions: Faculties > Social Sciences > School of Social Policy Sociology and Social Research > Centre for Health Services Studies
Depositing User: Lindsay Forbes
Date Deposited: 28 Oct 2019 19:45 UTC
Last Modified: 29 Oct 2019 14:50 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/77963 (The current URI for this page, for reference purposes)
Forbes, Lindsay: https://orcid.org/0000-0002-4654-9520
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