Skip to main content

Analysis of diverse eukaryotes suggests the existence of an ancestral mitochondrial apparatus derived from the bacterial type II secretion system

Horváthová, Lenka, Žárský, Vojtěch, Pánek, Tomáš, Derelle, Romain, Pyrih, Jan, Motyčková, Alžběta, Klápšťová, Veronika, Klimeš, Vladimír, Petrů, Markéta, Vaitová, Zuzana, and others. (2021) Analysis of diverse eukaryotes suggests the existence of an ancestral mitochondrial apparatus derived from the bacterial type II secretion system. Nature Communications, 12 (2947). ISSN 2041-1723. (doi:10.1038/s41467-021-23046-7) (KAR id:77662)

PDF Accessible Version
Language: English
Download this file
(PDF/2MB)
[thumbnail of 790865.full.pdf]
Preview
PDF Publisher pdf
Language: English

Restricted to Repository staff only
Contact us about this Publication
[thumbnail of s41467-021-23046-7.pdf]
Official URL:
https://www.nature.com/articles/s41467-021-23046-7

Abstract

The type 2 secretion system (T2SS) is present in some Gram-negative eubacteria and used to secrete proteins across the outer membrane. Here we report that certain representative heteroloboseans, jakobids, malawimonads and hemimastigotes unexpectedly possess homologues of core T2SS components. We show that at least some of them are present in mitochondria, and their behaviour in biochemical assays is consistent with the presence of a mitochondrial T2SS-derived system (miT2SS). We additionally identified 23 protein families co-occurring with miT2SS in eukaryotes. Seven of these proteins could be directly linked to the core miT2SS by functional data and/or sequence features, whereas others may represent different parts of a broader functional pathway, possibly also involving the peroxisome. Its distribution in eukaryotes and phylogenetic evidence together indicate that the miT2SS-centred pathway is an ancestral eukaryotic trait. Our findings thus have direct implications for the functional properties of the early mitochondrion.

Item Type: Article
DOI/Identification number: 10.1038/s41467-021-23046-7
Subjects: Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Anastasios Tsaousis
Date Deposited: 21 Oct 2019 16:49 UTC
Last Modified: 04 Jul 2023 13:48 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/77662 (The current URI for this page, for reference purposes)

University of Kent Author Information

Tsaousis, Anastasios D.

Creator's ORCID: https://orcid.org/0000-0002-5424-1905
CReDIT Contributor Roles:
  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.