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Analysis of diverse eukaryotes suggests the existence of an ancestral mitochondrial apparatus derived from the bacterial type II secretion system

Horváthová, Lenka, Žárský, Vojtěch, Pánek, Tomáš, Derelle, Romain, Pyrih, Jan, Motyčková, Alžběta, Klápšťová, Veronika, Klimeš, Vladimír, Petrů, Markéta, Vaitová, Zuzana, and others. (2021) Analysis of diverse eukaryotes suggests the existence of an ancestral mitochondrial apparatus derived from the bacterial type II secretion system. Nature Communications, 12 (2947). ISSN 2041-1723. (doi:10.1038/s41467-021-23046-7) (KAR id:77662)

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Abstract

The type 2 secretion system (T2SS) is present in some Gram-negative eubacteria and used to secrete proteins across the outer membrane. Here we report that certain representative heteroloboseans, jakobids, malawimonads and hemimastigotes unexpectedly possess homologues of core T2SS components. We show that at least some of them are present in mitochondria, and their behaviour in biochemical assays is consistent with the presence of a mitochondrial T2SS-derived system (miT2SS). We additionally identified 23 protein families co-occurring with miT2SS in eukaryotes. Seven of these proteins could be directly linked to the core miT2SS by functional data and/or sequence features, whereas others may represent different parts of a broader functional pathway, possibly also involving the peroxisome. Its distribution in eukaryotes and phylogenetic evidence together indicate that the miT2SS-centred pathway is an ancestral eukaryotic trait. Our findings thus have direct implications for the functional properties of the early mitochondrion.

Item Type: Article
DOI/Identification number: 10.1038/s41467-021-23046-7
Subjects: Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Depositing User: Anastasios Tsaousis
Date Deposited: 21 Oct 2019 16:49 UTC
Last Modified: 24 May 2021 18:50 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/77662 (The current URI for this page, for reference purposes)
Tsaousis, Anastasios D: https://orcid.org/0000-0002-5424-1905
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