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A Clinical Electrophysiological Study of Emotional Lability in Patients With Systemic Lupus Erythematosus

Langosch, Jens, Rand, Stacey, Ghosh, Boyd, Sharma, Simeran, Tench, Colin, Stratton, Richard, D'Cruz, David, Trimble, Michael, Barrett, Geoff, Ring, Howard and others. (2008) A Clinical Electrophysiological Study of Emotional Lability in Patients With Systemic Lupus Erythematosus. The Journal of Neuropsychiatry and Clinical Neurosciences, 20 (2). pp. 201-209. ISSN 0895-0172. (doi:10.1176/jnp.2008.20.2.201) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:76821)

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Neuropsychiatric symptoms are well recognized in systemic lupus erythematosus (SLE), with depression and anxiety often reported. The authors’ clinical observations suggested emotional lability might also be a noteworthy symptom. In a consecutive series of systemic lupus erythematosus clinic attendees, the authors, therefore, measured depression, anxiety, and emotional lability. Additionally, based on reports linking emotional reactivity and transient mood changes to alterations in early attentional processes, the authors investigated event-related potential indices of preattentive and early orienting responses to auditory stimuli (N1, MMN, P3a and P3b). The authors observed that 15 of 32 participants with systemic lupus erythematosus had high lability scores and, comparing event-related potential measures between the high and low lability subgroups, noted that those with greater emotional lability demonstrated reduced response latencies in N1 and MMN paradigms.

Item Type: Article
DOI/Identification number: 10.1176/jnp.2008.20.2.201
Divisions: Divisions > Division for the Study of Law, Society and Social Justice > School of Social Policy, Sociology and Social Research > Personal Social Services Research Unit
Depositing User: Stacey Rand
Date Deposited: 26 Sep 2019 10:50 UTC
Last Modified: 16 Nov 2021 10:26 UTC
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