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Making medicines safer: Analysis of patient reports to the UK’s Yellow Card Scheme

O'Donovan, B., Rodgers, Ruth M., Cox, Anthony R., Krska, Janet (2019) Making medicines safer: Analysis of patient reports to the UK’s Yellow Card Scheme. Expert Opinion in Drug Safety, 18 (12). pp. 1237-1243. ISSN 1474-0338. E-ISSN 1744-764X. (doi:10.1080/14740338.2019.1669559) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:76761)

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Background: No studies describing UK patient Yellow Card reports have been published since the evaluation of the first two years of direct patient reporting (2005-7), when 5,180 reports were analysed. Research design and population: Patient Yellow Card reports submitted July-December 2015 for vaccines and other drugs were analysed. Comparisons to the initial evaluation were made of: reporting method, number of suspect drugs, proportion classed as serious. Factors affecting seriousness of reports were also examined. Results: There were 3,060 patient Yellow Card reports analysed. Vaccine reports increased from very few in 2005-7, comprising 25% of reports. The proportion of reports citing one drug (94.3%) and the proportion considered serious (70.3%) increased from the 84% and 58% respectively found in 2005-7. The main method of reporting had changed from paper (61%) to internet (88.5%). Serious reports were more common in females, for vaccines in young persons, but in adults for other drugs and included more reaction terms than non-serious reports. Conclusions: Patient reporting, in particular to vaccines, has increased dramatically since 2005-7. Increases in the proportion of reports concerning one drug and the proportion considered serious could indicate that the usability of patient reports may have improved in comparison to early reporting.

Item Type: Article
DOI/Identification number: 10.1080/14740338.2019.1669559
Uncontrolled keywords: patient reports, adverse drug reactions, side effects, patient experience, Yellow Card Scheme, pharmacovigilance
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Janet Krska
Date Deposited: 24 Sep 2019 17:08 UTC
Last Modified: 16 Feb 2021 14:07 UTC
Resource URI: (The current URI for this page, for reference purposes)
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