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Births from embryos with highly elevated levels of mitochondrial DNA

Victor, Andrea, Griffin, Darren, Gardner, David K., Brake, Alan, Zouves, Christo, Barnes, Frank, Viotti, Manuel (2019) Births from embryos with highly elevated levels of mitochondrial DNA. Reproductive BioMedicine Online, 39 (3). pp. 403-412. ISSN 1472-6483. (doi:10.1016/j.rbmo.2019.03.214) (KAR id:76034)

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https://dx.doi.org/10.1016/j.rbmo.2019.03.214

Abstract

Measurement of mtDNA copy number might not provide any advantage in embryo prioritization and could lead to a deselection of blastocysts that would result in healthy pregnancies and births. Furthermore, the quantification of mitochondrial functional output in a model of cellular stress might suggest that mitochondria are not clear targets for biomarker identification as it relates to blastocyst viability. Any suggested link between mtDNA levels, mitochondria or their output with blastocyst transfer outcome requires further validation.

Item Type: Article
DOI/Identification number: 10.1016/j.rbmo.2019.03.214
Uncontrolled keywords: Biomarker, BlastocystImplantation Mitochondria Mitochondrial, DNA, (mtDNA)
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 30 Aug 2019 07:58 UTC
Last Modified: 04 Apr 2020 23:00 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/76034 (The current URI for this page, for reference purposes)
Griffin, Darren: https://orcid.org/0000-0001-7595-3226
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