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Chromosomics: Bridging the Gap between Genomes and Chromosomes

Deakin, Janine E., Potter, Sally, O’Neill, Rachel, Ruiz-Herrera, Aurora, Cioffi, Marcelo B., Eldridge, Mark D.B., Fukui, Kichi, Marshall Graves, Jennifer A., Griffin, Darren, Grutzner, Frank, and others. (2019) Chromosomics: Bridging the Gap between Genomes and Chromosomes. Genes, 10 (8). p. 627. ISSN 2073-4425. (doi:10.3390/genes10080627)

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https://doi.org/10.3390/genes10080627

Abstract

The recent advances in DNA sequencing technology are enabling a rapid increase in the number of genomes being sequenced. However, many fundamental questions in genome biology remain unanswered, because sequence data alone is unable to provide insight into how the genome is organised into chromosomes, the position and interaction of those chromosomes in the cell, and how chromosomes and their interactions with each other change in response to environmental stimuli or over time. The intimate relationship between DNA sequence and chromosome structure and function highlights the need to integrate genomic and cytogenetic data to more comprehensively understand the role genome architecture plays in genome plasticity. We propose adoption of the term ‘chromosomics’ as an approach encompassing genome sequencing, cytogenetics and cell biology, and present examples of where chromosomics has already led to novel discoveries, such as the sex-determining gene in eutherian mammals. More importantly, we look to the future and the questions that could be answered as we enter into the chromosomics revolution, such as the role of chromosome rearrangements in speciation and the role more rapidly evolving regions of the genome, like centromeres, play in genome plasticity. However, for chromosomics to reach its full potential, we need to address several challenges, particularly the training of a new generation of cytogeneticists, and the commitment to a closer union among the research areas of genomics, cytogenetics, cell biology and bioinformatics. Overcoming these challenges will lead to ground-breaking discoveries in understanding genome evolution and function

Item Type: Article
DOI/Identification number: 10.3390/genes10080627
Uncontrolled keywords: cytogenetics; sex chromosomes; chromosome rearrangements; genome plasticity; centromere; genome biology; evolution
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 29 Aug 2019 09:45 UTC
Last Modified: 29 Aug 2019 09:53 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/76016 (The current URI for this page, for reference purposes)
Griffin, Darren: https://orcid.org/0000-0001-7595-3226
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