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Molecular Mechanisms of Adipogenesis: The Anti-Obesogenic Role of AMP-Activated Protein Kinase and Recently Reported Plant Products

Ahmad, Bilal, Serpell, Christopher J., Lim, Isabel Fong, Wong, Eng Hwa (2019) Molecular Mechanisms of Adipogenesis: The Anti-Obesogenic Role of AMP-Activated Protein Kinase and Recently Reported Plant Products. preprints.org, . (Submitted) (doi:10.20944/preprints201907.0040.v2)

Abstract

The Abnormal increase in the mass of adipose tissue during adipogenesis results in obesity. Obesity is a predominant disorder and its widespread has become a critical concern worldwide. This is due to the burden of its associated co-morbidities like cancer, cardiovascular diseases and diabetes. Over-nutrition and the sedentary lifestyle are considered as the most significant causes of abnormal adipose tissue development. Appropriate lifestyle and behavioural interventions are the corner stones of successful weight loss, but to maintain such a lifestyle is highly challenging. Accordingly, natural products from plants either as crude extracts or purified phytochemicals have shown to have anti-obesogenic properties and are generally non-toxic and cost-effective. In this review, we discuss the comparative analysis of molecular mechanisms involved in adipogenesis and the recently reported anti-obesogenic effects of various plant products. We will provide a common platform for understanding obesity and adipogenesis, and a possible mechanism of action for anti-obesogenic plant products through AMP-activated protein kinase (AMPK), which will support the scientific development of traditional herbal medicine.

Item Type: Article
DOI/Identification number: 10.20944/preprints201907.0040.v2
Uncontrolled keywords: adipogenesis; AMPK; plant products; anti-obesogenic; beige/brite adipocytes; natural products; phytochemicals
Divisions: Faculties > Sciences > School of Physical Sciences
Depositing User: Christopher Serpell
Date Deposited: 01 Aug 2019 11:17 UTC
Last Modified: 24 Sep 2019 13:59 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/75648 (The current URI for this page, for reference purposes)
Serpell, Christopher J.: https://orcid.org/0000-0002-2848-9077
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