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Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase

Ahmad, Bilal, Serpell, Christopher J., Lim Fong, Isabel, Wong, Eng Hwa (2020) Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase. Frontiers in Molecular Biosciences, 7 . Article Number 76. ISSN 2296-889X. (doi:10.3389/fmolb.2020.00076) (KAR id:75648)

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Abstract

Obesity is now a widespread disorder, and its prevalence has become a critical concern worldwide, due to its association with common co-morbidities like cancer, cardiovascular diseases and diabetes. Adipose tissue is an endocrine organ and therefore plays a critical role in the survival of an individual, but its dysfunction or excess is directly linked to obesity. The journey from multipotent mesenchymal stem cells to the formation of mature adipocytes is a well-orchestrated program which requires the expression of several genes, their transcriptional factors, and signaling intermediates from numerous pathways. Understanding all the intricacies of adipogenesis is vital if we are to counter the current epidemic of obesity because the limited understanding of these intricacies is the main barrier to the development of potent therapeutic strategies against obesity. In particular, AMP-Activated Protein Kinase (AMPK) plays a crucial role in regulating adipogenesis – it is arguably the central cellular energy regulation protein of the body. Since AMPK promotes the development of brown adipose tissue over that of white adipose tissue, special attention has been given to its role in adipose tissue development in recent years. In this review, we describe the molecular mechanisms involved in adipogenesis, the role of signaling pathways and the substantial role of activated AMPK in the inhibition of adiposity, concluding with observations which will support the development of novel chemotherapies against obesity epidemics.

Item Type: Article
DOI/Identification number: 10.3389/fmolb.2020.00076
Uncontrolled keywords: adipogenesis; AMPK; plant products; anti-obesogenic; beige/brite adipocytes; natural products; phytochemicals; obesity; WAT; BAT, AMPK
Subjects: Q Science
Divisions: Faculties > Sciences > School of Physical Sciences
Depositing User: Christopher Serpell
Date Deposited: 01 Aug 2019 11:17 UTC
Last Modified: 10 Sep 2020 12:04 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/75648 (The current URI for this page, for reference purposes)
Serpell, Christopher J.: https://orcid.org/0000-0002-2848-9077
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