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Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor

Giotis, Efstathios S., Carnell, George, Young, Erik F., Ghanny, Saleena, Soteropoulos, Patricia, Wang, Lin-Fa, Barclay, Wendy S., Skinner, Michael A., Temperton, Nigel (2019) Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor. Nature Microbiology, 4 . pp. 2034-2038. ISSN 2058-5276. (doi:10.1038/s41564-019-0517-3)

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https://doi.org/10.1038/s41564-019-0517-3

Abstract

Haemagglutinin and neuraminidase surface glycoproteins of the bat influenza H17N10 virus neither bind to nor cleave sialic acid receptors, indicating that this virus employs cell entry mechanisms distinct from those of classical influenza A viruses. We observed that certain human haematopoietic cancer cell lines and canine MDCK II cells are susceptible to H17-pseudotyped viruses. We identified the human HLA-DR receptor as an entry mediator for H17 pseudotypes, suggesting that H17N10 possesses zoonotic potential.

Item Type: Article
DOI/Identification number: 10.1038/s41564-019-0517-3
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Nigel Temperton
Date Deposited: 30 Jul 2019 21:58 UTC
Last Modified: 29 Jan 2020 00:00 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/75627 (The current URI for this page, for reference purposes)
Temperton, Nigel: https://orcid.org/0000-0002-7978-3815
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