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Evidential Proximity, Independence, and the evaluation of carcinogenicity

Williamson, Jon (2019) Evidential Proximity, Independence, and the evaluation of carcinogenicity. Journal of Evaluation in Clinical Practice, . ISSN 1356-1294. (doi:10.1111/jep.13226) (KAR id:75285)

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Abstract

This paper analyses the methods of the International Agency for Research on Cancer (IARC) for evaluating the carcinogenicity of various agents. I identify two fundamental evidential principles that underpin these methods, which I call Evidential Proximity and Independence. I then show, by considering the 2018 evaluation of the carcinogenicity of styrene and styrene‐7,8‐oxide, that these principles have been implemented in a way that can lead to inconsistency. I suggest a way to resolve this problem: admit a general exception to Independence and treat the implementation of Evidential Proximity more flexibly where this exception applies. I show that this suggestion is compatible with the general principles laid down in the 2019 version of IARC's methods guide, its Preamble to the Monographs.

Item Type: Article
DOI/Identification number: 10.1111/jep.13226
Subjects: B Philosophy. Psychology. Religion > B Philosophy (General)
R Medicine > RA Public aspects of medicine > RA421 Public health. Hygiene. Preventive Medicine
Divisions: Faculties > Humanities > School of European Culture and Languages > Philosophy
Depositing User: Jon Williamson
Date Deposited: 10 Jul 2019 14:58 UTC
Last Modified: 28 Aug 2019 10:53 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/75285 (The current URI for this page, for reference purposes)
Williamson, Jon: https://orcid.org/0000-0003-0514-4209
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