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Radiation damage of biomolecules (RADAM) database development: Current status

Denifl, S., Garcia, G., Huber, B.A., Marinković, B.P., Mason, Nigel, Postler, J., Rabus, H., Rixon, G., Solov'yov, A.V., Suraud, E., and others. (2013) Radiation damage of biomolecules (RADAM) database development: Current status. Journal of Physics: Conference Series, 438 (1). (doi:10.1088/1742-6596/438/1/012016) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:74725)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1088/1742-6596/438/1/012016

Abstract

Ion beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue, while maximizing cell killing within the tumour. However, as the underlying dependent physical, chemical and biological processes are too complex to treat them on a purely analytical level, most of our current and future understanding will rely on computer simulations, based on mathematical equations, algorithms and last, but not least, on the available atomic and molecular data. The viability of the simulated output and the success of any computer simulation will be determined by these data, which are treated as the input variables in each computer simulation performed. The radiation research community lacks a complete database for the cross sections of all the different processes involved in ion beam induced damage: ionization and excitation cross sections for ions with liquid water and biological molecules, all the possible electron - medium interactions, dielectric response data, electron attachment to biomolecules etc. In this paper we discuss current progress in the creation of such a database, outline the roadmap of the project and review plans for the exploitation of such a database in future simulations.

Item Type: Article
DOI/Identification number: 10.1088/1742-6596/438/1/012016
Uncontrolled keywords: Biomolecules, Chemical analysis, Database systems, Electric excitation, Ion beams, Ionization of liquids, Ions, Molecular biology, Nanotechnology, Radiation damage, Tumors, Biological molecule, Chemical and biologicals, Database development, Dielectric response, Electron attachment, Excitation cross section, Mathematical equations, Research communities, Bioinformatics
Divisions: Faculties > Sciences > School of Physical Sciences
Depositing User: Nigel Mason
Date Deposited: 16 Jul 2019 10:22 UTC
Last Modified: 16 Jul 2019 10:22 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/74725 (The current URI for this page, for reference purposes)
Mason, Nigel: https://orcid.org/0000-0002-4468-8324
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