Raposo, M., Coelho, M., Gomes, P.J., Vieira, P., Ribeiro, P.A., Mason, Nigel, Hunniford, C.A., McCullough, R.W. (2014) DNA damage induced by carbon ions (C3+) beam accessed by independent component analysis of infrared spectra. International Journal of Radiation Biology, 90 (5). pp. 344-350. ISSN 0955-3002. (doi:10.3109/09553002.2014.892650) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:74712)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: https://doi.org/10.3109/09553002.2014.892650 |
Abstract
Purpose: To understand the degradation processes and role of secondary species on deoxyribonucleic acid (DNA)-damaged fragments as a result of irradiation with energetic ions. Materials and methods: Damage caused to DNA thin films as a result of exposure to 4 keV carbon ions beam was accessed by analyzing the infrared spectra, obtained in situ for different irradiation times, with both bi-dimensional (2D) correlation spectroscopy and independent component analysis (ICA). Results: Results indicated that deoxyribose, phosphate and base groups of the DNA molecule were being damaged and new reaction products as oxime and furfural groups are being formed. Conclusions: Damage on DNA bases is consistent with the formation of oxime products which react with DNA deoxyribose products forming furfural groups and confirming that DNA damage is caused by direct and indirect processes.
| Item Type: | Article |
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| DOI/Identification number: | 10.3109/09553002.2014.892650 |
| Uncontrolled keywords: | Carbon ion, Deoxyribose, DNA damage, Furfural, Ion beam, Oxime, carbon, deoxyribose, DNA base, furfural, oxime, article, chemical bond, chemical reaction, conformational transition, DNA conformation, DNA damage, DNA fragmentation, independent component analysis, infrared radiation, infrared spectroscopy, nonhuman, priority journal, radiation beam, radiation exposure, spectroscopy, time, two dimensional correlated effect, Animals, Carbon, Cattle, DNA Damage, Spectrophotometry, Infrared, Statistics as Topic |
| Divisions: | Divisions > Division of Natural Sciences > Physics and Astronomy |
| Depositing User: | Nigel Mason |
| Date Deposited: | 11 Jul 2019 09:49 UTC |
| Last Modified: | 17 Aug 2022 11:02 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/74712 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Mason, Nigel.
| Creator's ORCID: |
 https://orcid.org/0000-0002-4468-8324
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