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Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms

Śmiałek, M.A., Ptasińska, S., Gow, J., Hoffmann, Sø.V., Mason, Nigel (2015) Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms. European Physical Journal D, 69 (5). ISSN 1434-6060. (doi:10.1140/epjd/e2015-60036-5) (KAR id:74688)

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https://doi.org/10.1140/epjd/e2015-60036-5

Abstract

Irradiations of plasmid DNA by both X-rays and UV light in the presence and absence of compounds containing platinum and bromine atoms were performed in order to asses the sensitization potential of these compounds. Plasmid DNA pBR322 was incubated with platinum (II) bromide, hydrogen hexabromoplatinate (IV), hydrogen hexahydroxyplatinate (IV) and sodium hexahydroxyplatinate (IV). Incubation was followed by X-ray or UV irradiations. It was found that amongst the sensitizers tested, during irradiations carried out in the presence of platinum (II) bromide, the highest levels of double strand breaks formation upon X-ray treatment were recorded. In contrast much less damage was induced by UV light. Data presented here suggests that this compound may be a promising radiosensitizer for cancer treatment.

Item Type: Article
DOI/Identification number: 10.1140/epjd/e2015-60036-5
Divisions: Faculties > Sciences > School of Physical Sciences
Depositing User: Nigel Mason
Date Deposited: 03 Jul 2019 15:54 UTC
Last Modified: 03 Jul 2019 15:55 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/74688 (The current URI for this page, for reference purposes)
Mason, Nigel: https://orcid.org/0000-0002-4468-8324
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