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Thermo-mechanical damage of biomolecules under ion-beam radiation

de Vera, P. and Mason, Nigel and Surdutovich, E. and Solov’yov, A.V. (2017) Thermo-mechanical damage of biomolecules under ion-beam radiation. In: Nanoscale Insights into Ion-Beam Cancer Therapy. Springer, pp. 339-357. ISBN 978-3-319-43028-7. (doi:10.1007/978-3-319-43030-0_10) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://doi.org/10.1007/978-3-319-43030-0_10

Abstract

The prediction of the relative biological effectiveness of ion beams requires the quantification of all the biomolecular damage processes involved in the interaction of energetic ions with biological media. Traditionally, the damage pathways have been classified as direct or indirect, the former being related to the direct action of the secondary electrons produced along the ion path with DNA molecules, while the latter are referred to the damage produced by the other chemical species generated, mainly free radicals. However, the development over the last years of the multiscale approach to ion beam cancer therapy has revealed the contribution of a new damage mechanism, not present in conventional therapy with photons or electrons: the thermo-mechanical DNA damage arising from the development of shock waves on the nanometer scale around the swift ion path. The present chapter explains the theoretical framework in which this effect is predicted and reviews the work performed over the last years to try to understand the role of this damage pathway in the mechanisms of ion beam cancer therapy.

Item Type: Book section
DOI/Identification number: 10.1007/978-3-319-43030-0_10
Uncontrolled keywords: Biomolecules, Diseases, Free radicals, Ions, Oncology, Shock waves, Ion-beam radiation, Multi-scale approaches, Nano-meter scale, Relative biological effectiveness, Secondary electrons, Theoretical framework, Thermo-mechanical, Thermo-mechanical damages, Ion beams
Divisions: Faculties > Sciences > School of Physical Sciences
Depositing User: Nigel Mason
Date Deposited: 03 Jul 2019 08:57 UTC
Last Modified: 03 Jul 2019 08:57 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/74670 (The current URI for this page, for reference purposes)
Mason, Nigel: https://orcid.org/0000-0002-4468-8324
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