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The CydDC family of transporters

Poole, Robert K., Cozens, Adam G., Shepherd, Mark (2019) The CydDC family of transporters. Research in Microbiology, 170 (8). pp. 407-416. ISSN 0923-2508. (doi:10.1016/j.resmic.2019.06.003) (KAR id:74588)


The CydDC family of ABC transporters export the low molecular weight thiols glutathione and cysteine to the periplasm of a variety of bacterial species. The CydDC complex has previously been shown to be important for disulfide folding, motility, respiration, and tolerance to nitric oxide and antibiotics. In addition, CydDC is thus far unique amongst ABC transporters in that it binds a haem cofactor that appears to modulate ATPase activity. CydDC has a diverse impact upon bacterial metabolism, growth, and virulence, and is of interest to those working on membrane transport mechanisms, redox biology, aerobic respiration, and stress sensing/tolerance during infection.

Item Type: Article
DOI/Identification number: 10.1016/j.resmic.2019.06.003
Uncontrolled keywords: CydDC; ABC transporter; Redox; Thiol; E Coli
Subjects: Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Mark Shepherd
Date Deposited: 26 Jun 2019 10:02 UTC
Last Modified: 04 Mar 2024 15:45 UTC
Resource URI: (The current URI for this page, for reference purposes)

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