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The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease

Raulin, Ana-Caroline, Kraft, Lucas, Al-Hilaly, Youssra K., Xue, Wei-Feng, McGeehan, John E., Atack, John R., Serpell, Louise (2019) The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease. Journal of Molecular Biology, 431 (12). pp. 2248-2265. ISSN 0022-2836. (doi:10.1016/j.jmb.2019.04.019) (KAR id:74338)

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https://doi.org/10.1016/j.jmb.2019.04.019

Abstract

Apolipoprotein E4 (ApoE4) is one of three (E2, E3 and E4) human isoforms of an α-helical, 299-amino-acid

disease (AD). ApoE2, ApoE3 and ApoE4 differ at amino acid positions 112 and 158, and these sequence

Here, we compared the shape, oligomerization state, conformation and stability of ApoE isoforms using a

circular dichroism, x-ray fiber diffraction and transmission electron microscopy We provide an indepth

However, we show that ApoE4 has a propensity to polymerize to form wavy filaments, which do not share the

formation by ApoE3. This study shows that recombinant ApoE isoforms show no significant differences at the

pathogenesis, and these results open opportunities for uncovering new triggers for AD onset.

Item Type: Article
DOI/Identification number: 10.1016/j.jmb.2019.04.019
Uncontrolled keywords: apolipoprotein E, Alzheimer's disease, small-angle x-ray scattering, analytical ultracentrifugation, alpha-helix
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Susan Davies
Date Deposited: 10 Jun 2019 08:05 UTC
Last Modified: 19 Aug 2019 09:09 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/74338 (The current URI for this page, for reference purposes)
Xue, Wei-Feng: https://orcid.org/0000-0002-6504-0404
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