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Dissecting cause and effect in host-microbiome interactions using the combined worm-bug model system

Ezcurra, Marina (2018) Dissecting cause and effect in host-microbiome interactions using the combined worm-bug model system. Biogerontology, 19 (6). pp. 567-578. ISSN 1389-5729. (doi:10.1007/s10522-018-9752-x)

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Abstract

High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complexity and heterogeneity of the human microbiome we need robust experimental models that allow the systematic manipulation of variables to test the multitude of hypotheses arisen from large-scale ‘meta-omic’ projects. The nematode C. elegans combined with bacterial models offers an avenue to dissect cause and effect in host-microbiome interactions. This combined model allows the genetic manipulation of both host and microbial genetics and the use of a variety of tools, to identify pathways affecting host health. A number of recent high impact studies have used C. elegans to identify microbial pathways affecting ageing and longevity, demonstrating the power of the combined C. elegans-bacterial model. Here I will review the current state of the field, what we have learned from using C. elegans to study gut microbiome and host interactions, and the potential of using this model system in the future.

Item Type: Article
DOI/Identification number: 10.1007/s10522-018-9752-x
Uncontrolled keywords: Ageing, Microbiome, Microbiota, C.elegans, E. coli, B. subtilis, Folate NO, Biofilm, Dysbiosis
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Marina Ezcurra
Date Deposited: 31 May 2019 15:14 UTC
Last Modified: 22 Jan 2020 04:12 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/74207 (The current URI for this page, for reference purposes)
Ezcurra, Marina: https://orcid.org/0000-0003-2739-6984
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