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Quantitative assessment of rat bone regeneration using complex master-slave optical coherence tomography

Luca, Ruxandra, Todea, C., Duma, V.F., Bradu, Adrian, Podoleanu, Adrian G.H. (2019) Quantitative assessment of rat bone regeneration using complex master-slave optical coherence tomography. Quantitative Imaging in Medicine and Surgery, 9 (5). pp. 782-798. ISSN 2223-4292. E-ISSN 2223-4306. (doi:10.21037/qims.2019.05.03) (KAR id:74173)

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Background: The need for hard and soft tissues in oral implantology determined the development of methods and techniques to increase bone volume and their quality with different alternative materials used as substituents of patient’s natural bone. In addition, laser radiation can be used to accelerate the repair of fractures and to produce an increased volume of formed callus, as well as an increased bone mineral density.

Results: The method allows for the simultaneous monitoring of the bone tissue via two perpendicular cross-sections and nine en-face images taken at adjustable depths into the sample. A global image with course axial resolution allows for the positioning of the field-of-view of the system on the area of interest on the tissue. The quantitative assessment of the process of bone formation is completed using the differences in brightness between the native bone, the artificial bone graft, and the newly-formed bone.

Conclusions: Group C is demonstrated to have a higher volume of newly-formed bone than Group B, which is better from this point of view than Group A. By analyzing the evolution of this volume of new bone in time, the most significant difference was after 21 days, therefore approximately after two thirds of the total time interval analyzed. After 30 days, the volumes of bone tend to move closer, as they begin to fill the available gap. The study demonstrates that OCT can assess quantitatively the positive impact of LLLT on bone regeneration.

Item Type: Article
DOI/Identification number: 10.21037/qims.2019.05.03
Subjects: Q Science > QC Physics > QC355 Optics
R Medicine
Divisions: Divisions > Division of Natural Sciences > School of Physical Sciences
Depositing User: Adrian Bradu
Date Deposited: 30 May 2019 11:16 UTC
Last Modified: 16 Feb 2021 14:04 UTC
Resource URI: (The current URI for this page, for reference purposes)
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