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Is the Bombali virus pathogenic in humans?

Martell, H.J., Masterson, Stuart G., McGreig, Jake M, Michaelis, Martin, Wass, Mark N. (2019) Is the Bombali virus pathogenic in humans? Bioinformatics, . ISSN 1367-4803. (doi:10.1093/bioinformatics/btz267) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1093/bioinformatics/btz267

Abstract

Motivation: The potential of the Bombali virus, a novel Ebolavirus, to cause disease in humans

in humans by analysing the amino acid positions that are differentially conserved (specificity

Reston virus. Here, we include the many Ebolavirus genome sequences that have since become

at the SDPs that discriminate between human pathogenic and non-human pathogenic

20 Results: The use of 1408 Ebolavirus genomes (196 in the original analysis) resulted in a set of

indicates the robustness of our approach and refines the set of SDPs that distinguish human pathogenic

with the human pathogenic Ebolaviruses (63.25%). However, for two SDPs in VP24 (M136L, R139S)

they alter the VP24-karyopherin interaction, the Bombali virus amino acids match those of Reston

disease outbreaks have been reported, although Bombali virus was isolated from fruit

30 contact with Bombali virus have been detected in humans.

Item Type: Article
DOI/Identification number: 10.1093/bioinformatics/btz267
Uncontrolled keywords: Ebola virus, bioinformatics
Subjects: Q Science > QL Zoology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Mark Wass
Date Deposited: 03 May 2019 16:15 UTC
Last Modified: 30 May 2019 22:05 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/73757 (The current URI for this page, for reference purposes)
Michaelis, Martin: https://orcid.org/0000-0002-5710-5888
Wass, Mark N.: https://orcid.org/0000-0001-5428-6479
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