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Ultrahigh Drug Loading and Release from Biodegradable Porous Silicon Aerocrystals

Nadarassan, D K, Loni, A, Kelly, c, O’Brien, H, Caffull, E, Webb, K, Canham, L T, Maniruzamman, M, Trivedi, Vivek, Douroumis, Dennis and others. (2015) Ultrahigh Drug Loading and Release from Biodegradable Porous Silicon Aerocrystals. In: 2015 Controlled Release Society Meeting. .

Abstract

Biodegradable porous silicon (pSi) is under assessment for the controlled release of both proteins and poorly-soluble API formulations. Super-critical drying of ultrahigh porosity (90%) porous silicon is shown here to preserve much higher mesopore volumes (up to 4mL/g) and surface areas (up to 600m2/g) than achievable with standard air drying. The payloads and physical state of the model drug (S) (+) ibuprofen, as loaded within a super-critically dried porous silicon carrier matrix, were quantified and assessed using TGA, DSC, cross-sectional EDX, XRD, Raman mapping and FT-IR. In-vitro biodegradability was assessed using molybdenum blue assay and drug release using RP-HPLC. Entrapped drug payloads as high as 70%w/w have been achieved, substantially higher than values reported for other mesoporous materials. The entrapped (S) (+) ibuprofen showed faster release than bulk (S) (+) ibuprofen.

Item Type: Conference or workshop item (Speech)
Uncontrolled keywords: Ultrahigh Drug Loading, Biodegradable Porous Silicon, Aerocrystals, supercritical CO2
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Central Services > Universities at Medway
Faculties > Sciences > Medway School of Pharmacy
Depositing User: Vivek Trivedi
Date Deposited: 25 Apr 2019 13:33 UTC
Last Modified: 03 Jun 2019 09:44 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/73637 (The current URI for this page, for reference purposes)
Trivedi, Vivek: https://orcid.org/0000-0001-9304-9214
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