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Preparation of Rapamycin and methyl-β-cyclodextrin complexes using a single-step, organic solvent-free supercritical fluid process: An approach to enhance the solubility and dissolution properties

Rudrangi, S R S, Trivedi, Vivek, Alexander, Bruce D., Wicks, Stephen (2015) Preparation of Rapamycin and methyl-β-cyclodextrin complexes using a single-step, organic solvent-free supercritical fluid process: An approach to enhance the solubility and dissolution properties. In: Journal of Pharmaceutics & Drug Delivery Research. 3. SciTechnol, USA (doi:10.4172/2325-9604.S1.003) (KAR id:73632)

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Abstract

The purpose of this study was to evaluate a single-step, organic solvent-free supercritical fluid process for the preparation of

complexes were prepared by supercritical carbon dioxide processing, co-evaporation, freeze drying and physical mixing. The prepared

and dissolution studies. Computational molecular docking studies were performed to study the formation of molecular inclusion

rapamycin and methyl-β-cyclodextrin appeared not to reduce the degree of crystallinity of the drug. The co-evaporated and freeze

in complexes prepared by supercritical carbon dioxide processing method. All the binary mixtures with Me-β-CD exhibited a faster

exhibited the highest apparent drug dissolution. Information obtained from the characterization tests suggest complete complexation

inclusion method using supercritical carbon dioxide carrier proved to be a novel and useful complexation method for rapamycin into

side effects in humans, compared to those obtained by techniques, which require the use of perilous organic solvents.

Item Type: Conference or workshop item (Speech)
DOI/Identification number: 10.4172/2325-9604.S1.003
Uncontrolled keywords: Rapamycin, Supercritical carbon dioxide, Cyclodextrin, MBCD
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Central Services > Universities at Medway
Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Vivek Trivedi
Date Deposited: 25 Apr 2019 12:31 UTC
Last Modified: 16 Feb 2021 14:04 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/73632 (The current URI for this page, for reference purposes)
Trivedi, Vivek: https://orcid.org/0000-0001-9304-9214
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