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Preparation of polycaprolactone nanoparticles via supercritical carbon dioxide extraction of emulsions

Ajiboye, A L, Trivedi, Vivek, Mitchell, John C. (2017) Preparation of polycaprolactone nanoparticles via supercritical carbon dioxide extraction of emulsions. Drug Delivery and Translational Research, 8 . pp. 1790-1796. ISSN 2190-393X. (doi:10.1007/s13346-017-0422-3)

Abstract

Polycaprolactone (PCL) nanoparticles were produced via supercritical fluid extraction of emulsions (SFEE) using supercritical carbon dioxide (scCO2). The efficiency of the scCO2 extraction was investigated and compared to that of solvent extraction at atmospheric pressure. The effects of process parameters including polymer concentration (0.6–10% w/w in acetone), surfactant concentration (0.07 and 0.14% w/w) and polymer-to-surfactant weight ratio (1:1–16:1 w/w) on the particle size and surface morphology were also investigated. Spherical PCL nanoparticles with mean particle sizes between 190 and 350 nm were obtained depending on the polymer concentration, which was the most important factor where increase in the particle size was directly related to total polymer content in the formulation. Nanoparticles produced were analysed using dynamic light scattering and scanning electron microscopy. The results indicated that SFEE can be applied for the preparation of PCL nanoparticles without agglomeration and in a comparatively short duration of only 1 h.

Item Type: Article
DOI/Identification number: 10.1007/s13346-017-0422-3
Uncontrolled keywords: Solvent extraction, Polycaprolactone, Nanoparticles, Supercritical carbon dioxide, Supercritical fluid extraction of emulsions
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Central Services > Universities at Medway
Faculties > Sciences > Medway School of Pharmacy
Depositing User: Vivek Trivedi
Date Deposited: 24 Apr 2019 09:57 UTC
Last Modified: 03 Jun 2019 09:43 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/73601 (The current URI for this page, for reference purposes)
Trivedi, Vivek: https://orcid.org/0000-0001-9304-9214
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