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NMR metabolomics reveals effects of Cryptosporidium infections on host cell metabolome

Miller, Christopher N., Panagos, Charalampos G., Mosedale, William, Kvac, Martin, Howard, Mark J., Tsaousis, Anastasios D (2019) NMR metabolomics reveals effects of Cryptosporidium infections on host cell metabolome. Gut Pathogens, 11 (13). ISSN 1757-4749. (doi:10.1186/s13099-019-0293-x) (KAR id:73548)

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https://doi.org/10.1186/s13099-019-0293-x

Abstract

Background: Cryptosporidium is an important gut microbe whose contributions towards infant and immunocompromise

various tools and methods for studying Cryptosporidium infection and its interactions with their hosts. One area that is

Results: Using a 1H nuclear magnetic resonance approach to metabolomics, we have explored the nature of the

analysis and predictive modelling demonstrated new understandings of the effects of a Cryptosporidium infection,

taurine to the diarrhoeal aspects of the disease previously attributed to a solely parasite-based alteration of the gut

Conclusion: This approach will spearhead our understanding of the Cryptosporidium-host metabolic exchange and

provide novel targets for tackling this deadly parasite.

Item Type: Article
DOI/Identification number: 10.1186/s13099-019-0293-x
Uncontrolled keywords: Cryptosporidiosis, NMR, Metabolomics, COLO-680N, Taurine
Subjects: Q Science > QR Microbiology
Divisions: Faculties > Sciences > School of Biosciences > Biomedical Research Group
Depositing User: Anastasios Tsaousis
Date Deposited: 19 Apr 2019 09:28 UTC
Last Modified: 09 Jul 2019 09:01 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/73548 (The current URI for this page, for reference purposes)
Tsaousis, Anastasios D: https://orcid.org/0000-0002-5424-1905
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