Skip to main content

The Effect of the NADPH Oxidase YNO1 on Translational Fidelity

Dowling, James (2018) The Effect of the NADPH Oxidase YNO1 on Translational Fidelity. Master of Science by Research (MScRes) thesis, University of Kent,.

Abstract

The hypothesized relationship between translational fidelity and ageing is complex, dating back

to remain constant with ageing, but the mechanism through which this is possible is currently a

translational fidelity, and the relationship between Yno1p and translational fidelity was

was shown that YNO1 expression is negatively correlated with high frequency of stop-codon

ROS produced by Yno1p improves translational fidelity. Furthermore, YCK1, YCK2 and HEK2

Yno1p to the translational machinery. Additionally, the mechanism by which hydrogen peroxide

improvements in fidelity. Using growth assays, overexpression of YNO1 and hydrogen peroxide

inducing drug. YNO1 was found to be an important regulator of translational fidelity.

Item Type: Thesis (Master of Science by Research (MScRes))
Thesis advisor: Gourlay, Campbell
Thesis advisor: von der Haar, Tobias
Uncontrolled keywords: yeast cerevisiae yno1 yno1p aim14 translation translational accuracy fidelity luciferase ros ageing
Divisions: Faculties > Sciences > School of Biosciences
SWORD Depositor: System Moodle
Depositing User: System Moodle
Date Deposited: 22 Mar 2019 16:10 UTC
Last Modified: 06 Feb 2020 04:19 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/73128 (The current URI for this page, for reference purposes)
  • Depositors only (login required):

Downloads

Downloads per month over past year