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Hippocampal and retrosplenial goal distance coding after long-term consolidation of a real-world environment

Patai, E. Zita, Javadi, Amir-Homayoun, Ozubko, Jason D., O'Callaghan, Andrew, Ji, Shuman, Robin, Jessica, Grady, Cheryl, Winocur, Gordon, Rosenbaum, Shayna R., Moscovitch, Morris, and others. (2019) Hippocampal and retrosplenial goal distance coding after long-term consolidation of a real-world environment. Cerebral Cortex, 29 (6). pp. 2748-2758. ISSN 1047-3211. (doi:10.1093/cercor/bhz044)

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Abstract

Recent research indicates the hippocampus may code the distance to the goal during navigation of newly learned environments. It is unclear however, whether this also pertains to highly familiar environments where extensive systems-level consolidation is thought to have transformed mnemonic representations. Here we recorded fMRI while University College London and imperial College London students navigated virtual simulations of their own familiar campus (> 2 years of exposure) and the other campus learned days before scanning. Posterior hippocampal activity tracked the distance to the goal in the newly learned campus, as well as in familiar environments when the future route contained many turns. By contrast retrosplenial cortex only tracked the distance to the goal in the familiar campus. All of these responses were abolished when participants were guided to their goal by external cues. These results open new avenues of research on navigation and consolidation of spatial information and underscore the notion that the hippocampus continues to play a role in navigation when detailed processing of the environment is needed for navigation.

Item Type: Article
DOI/Identification number: 10.1093/cercor/bhz044
Uncontrolled keywords: consolidation, hippocampus, long-term memory, navigation, retrosplenial cortex
Divisions: Faculties > Social Sciences > School of Psychology
Depositing User: Amir-Homayoun Javadi
Date Deposited: 19 Mar 2019 12:40 UTC
Last Modified: 31 Jan 2020 16:33 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/73070 (The current URI for this page, for reference purposes)
Javadi, Amir-Homayoun: https://orcid.org/0000-0003-0569-6441
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