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Biocompatible polysaccharide-based hydrogels for attracting and trapping invasive glioma cells

Kasapidou, Paraskevi (2018) Biocompatible polysaccharide-based hydrogels for attracting and trapping invasive glioma cells. Doctor of Philosophy (PhD) thesis, University of Kent,. (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:73057)

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Language: English

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Abstract

Glioblastoma multiforme (GBM) is the most common deadly and aggressive malignant brain tumour of the central nervous system in humans. The relentless progression of this disease is due to the infiltration of the cells from the primary tumour site into distant regions of the brain, which renders complete resection of the tumour impossible leading to tumour recurrence. Current methods of treatment including surgical removal, chemotherapy combined to radiotherapy are mainly unsuccessful because of the highly invading and resistant nature of these glial tumours. Therefore, there is an urgent need to develop new methods and understand the complex behaviour and microenvironment of glioblastoma tumours. The key challenge in successful glioblastoma treatment lies in destroying the cancer cells that invade the brain tissue and exist in the brain parenchyma after the removal of the primary tumour bed.

Moreover, the physicochemical and mechanical properties of the fabricated hydrogels were mainly characterised by swelling studies, Scanning Electron Microscopy, enzymatic degradation experiments, Differential Scanning Calorimetry, Infrared Spectroscopy and oscillatory rheology. In overall, hydrogels presented favourable physicochemical features and mechanical properties that can mimic those of the native brain tissue. Preliminary biological results showed that glioma cells could invade and migrate in response to the loaded chemoattractant UII in the matrix.

Item Type: Thesis (Doctor of Philosophy (PhD))
Thesis advisor: Gubala, Vladimir
Divisions: Faculties > Sciences > Medway School of Pharmacy
SWORD Depositor: System Moodle
Depositing User: System Moodle
Date Deposited: 18 Mar 2019 16:59 UTC
Last Modified: 23 Jan 2020 04:16 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/73057 (The current URI for this page, for reference purposes)
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