Signal Transduction Pathways in Ageing

Slack, Cathy and Tullet, Jennifer M.A. (2019) Signal Transduction Pathways in Ageing. In: Harris, J. Robin and Korolchuk, Viktor I., eds. Biochemistry and Cell Biology of Ageing: Part I Biomedical Science. Subcellular Biochemistry . Springer, pp. 323-350. ISBN 978-981-1328-34-3. (doi:10.1007/978-981-13-2835-0_11) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Abstract

It is now widely recognised that ageing and its associated functional decline are regulated by a wide range of molecules that fit into specific cellular pathways. Here, we describe several of the evolutionary conserved cellular signalling pathways that govern organismal ageing and discuss how their identification, and work on the individual molecules that contribute to them, has aided in the design of therapeutic strategies to alleviate the adverse effects of ageing and age-related disease.

Item Type: Book section
DOI/Identification number: 10.1007/978-981-13-2835-0_11
Uncontrolled keywords: Insulin signalling, mTOR, AMPK, Ras/MAPK, Ageing
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Jennifer Tullet
Date Deposited: 15 Mar 2019 15:39 UTC
Last Modified: 03 Jun 2019 09:33 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/73029 (The current URI for this page, for reference purposes)
Tullet, Jennifer M.A.: https://orcid.org/0000-0002-2037-526X
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