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Telomere Biology and Human Phenotype

Turner, Kara Jane, Vasu, Vimal, Griffin, Darren K. (2019) Telomere Biology and Human Phenotype. Cells, 8 (1). Article Number 73. ISSN 2073-4409. E-ISSN 2073-4409. (doi:10.3390/cells8010073) (KAR id:72340)

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Official URL:
https://doi.org/10.3390/cells8010073

Abstract

Telomeres are nucleoprotein structures that cap the end of each chromosome arm and function to maintain genome stability. The length of telomeres is known to shorten with each cell division and it is well-established that telomere attrition is related to replicative capacity in vitro. Moreover, telomere loss is also correlated with the process of aging in vivo. In this review, we discuss the mechanisms that lead to telomere shortening and summarise telomere homeostasis in humans throughout a lifetime. In addition, we discuss the available evidence that shows that telomere shortening is related to human aging and the onset of age-related disease.

Item Type: Article
DOI/Identification number: 10.3390/cells8010073
Uncontrolled keywords: telomeres; telomere length; aging; senescence
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Darren Griffin
Date Deposited: 11 Feb 2019 16:14 UTC
Last Modified: 28 Jul 2022 22:09 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/72340 (The current URI for this page, for reference purposes)
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
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