Miller, David, Pavitt, Susan, Sharma, Vinay, Forbes, Gordon, Hooper, Richard, Bhattacharya, Siladitya, Kirkman-Brown, Jackson, Coomarasamy, Arri, Lewis, Sheena, Cutting, Rachel, and others. (2019) Physiological, hyaluronan-selected intracytoplasmic sperm injection for infertility treatment (HABSelect): a parallel, two-group, randomised trial. The Lancet, 393 (10170). pp. 416-422. ISSN 0140-6736. (doi:10.1016/S0140-6736(18)32989-1) (KAR id:72336)
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| Official URL https://doi.org/10.1016/S0140-6736(18)32989-1 |
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Abstract
Background
This parallel, two-group, randomised trial included couples undergoing an ICSI procedure with fresh embryo transfer at 16 assisted conception units in the UK. Eligible women (aged 18–43 years) had a body-mass index of 19–35 kg/m2 and a follicle-stimulating hormone (FSH) concentration of 3·0–20·0 mIU/mL or, if no FSH measurement was available, an anti-müllerian hormone concentration of at least 1·5 pmol/L. Eligible men (aged 18–55 years) had not had a vasovasostomy or been treated for cancer in the 24 months before recruitment and were able, after at least 3 days of sexual abstinence, to produce freshly ejaculated sperm for the treatment cycle. Couples were randomly assigned (1:1) with an online system to receive either PICSI or a standard ICSI procedure. The primary outcome was full-term (?37 weeks' gestational age) livebirth, which was assessed in all eligible couples who completed follow-up. This trial is registered, number ISRCTN99214271.
Findings
Compared with ICSI, PICSI does not significantly improve term livebirth rates. The wider use of PICSI, therefore, is not recommended at present.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1016/S0140-6736(18)32989-1 |
| Divisions: | Divisions > Division of Natural Sciences > School of Biosciences |
| Depositing User: | Darren Griffin |
| Date Deposited: | 11 Feb 2019 15:30 UTC |
| Last Modified: | 23 Jan 2020 04:16 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/72336 (The current URI for this page, for reference purposes) |
| Griffin, Darren K.: |  https://orcid.org/0000-0001-7595-3226 |
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