Miller, David, Pavitt, Susan, Sharma, Vinay, Forbes, Gordon, Hooper, Richard, Bhattacharya, Siladitya, Kirkman-Brown, Jackson, Coomarasamy, Arri, Lewis, Sheena, Cutting, Rachel, and others. (2019) Physiological, hyaluronan-selected intracytoplasmic sperm injection for infertility treatment (HABSelect): a parallel, two-group, randomised trial. The Lancet, 393 (10170). pp. 416-422. ISSN 0140-6736. (doi:10.1016/S0140-6736(18)32989-1) (KAR id:72336)
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Official URL https://doi.org/10.1016/S0140-6736(18)32989-1 |
Abstract
Background
This parallel, two-group, randomised trial included couples undergoing an ICSI procedure with fresh embryo transfer at 16 assisted conception units in the UK. Eligible women (aged 18–43 years) had a body-mass index of 19–35 kg/m2 and a follicle-stimulating hormone (FSH) concentration of 3·0–20·0 mIU/mL or, if no FSH measurement was available, an anti-müllerian hormone concentration of at least 1·5 pmol/L. Eligible men (aged 18–55 years) had not had a vasovasostomy or been treated for cancer in the 24 months before recruitment and were able, after at least 3 days of sexual abstinence, to produce freshly ejaculated sperm for the treatment cycle. Couples were randomly assigned (1:1) with an online system to receive either PICSI or a standard ICSI procedure. The primary outcome was full-term (?37 weeks' gestational age) livebirth, which was assessed in all eligible couples who completed follow-up. This trial is registered, number ISRCTN99214271.
Findings
Compared with ICSI, PICSI does not significantly improve term livebirth rates. The wider use of PICSI, therefore, is not recommended at present.
Item Type: | Article |
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DOI/Identification number: | 10.1016/S0140-6736(18)32989-1 |
Divisions: | Divisions > Division of Natural Sciences > School of Biosciences |
Depositing User: | Darren Griffin |
Date Deposited: | 11 Feb 2019 15:30 UTC |
Last Modified: | 23 Jan 2020 04:16 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/72336 (The current URI for this page, for reference purposes) |
Griffin, Darren K.: | ![]() |
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