One hundred mosaic embryos transferred prospectively in a single clinic: exploring when and why they result in healthy pregnancies

Victor, Andrea R., Tyndall, Jack C., Brake, Alan J., Lepkowsky, Laura T., Murphy, Alex E., Griffin, Darren K., McCoy, Rajiv C., Barnes, Frank L., Zouves, Christo G., Viotti, Manuel and others. (2019) One hundred mosaic embryos transferred prospectively in a single clinic: exploring when and why they result in healthy pregnancies. Fertility and Sterility, 111 (2). pp. 280-293. ISSN 0015-0282. (doi:10.1016/j.fertnstert.2018.10.019) (KAR id:72238)

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Official URL https://doi.org/10.1016/j.fertnstert.2018.10.019

Abstract

Objective

Prospective study.

Setting

Fifty-nine patients.

Intervention(s)

Chemical start of pregnancy, implantation, fetal heartbeat, and birth.

Result(s)

After euploid embryos, mosaic embryos can be considered for transfer, prioritizing those of the single segmental mosaic type. If a patient has mosaic embryos available that were generated at different ages, preference should be given to those made at younger ages. Intrablastocyst karyotype discordance and differential cell proliferation and death might be reasons that embryos classified as mosaic can result in healthy pregnancies and babies.

Item Type:	Article
DOI/Identification number:	10.1016/j.fertnstert.2018.10.019
Uncontrolled keywords:	Mosaic, PGT-A, blastocyst, aneuploidy, next-generation sequencing
Divisions:	Divisions > Division of Natural Sciences > School of Biosciences
Depositing User:	Darren Griffin
Date Deposited:	07 Feb 2019 11:20 UTC
Last Modified:	25 Jan 2020 00:00 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/72238 (The current URI for this page, for reference purposes)
Griffin, Darren K.:	https://orcid.org/0000-0001-7595-3226

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