Victor, Andrea R., Tyndall, Jack C., Brake, Alan J., Lepkowsky, Laura T., Murphy, Alex E., Griffin, Darren K., McCoy, Rajiv C., Barnes, Frank L., Zouves, Christo G., Viotti, Manuel and others. (2019) One hundred mosaic embryos transferred prospectively in a single clinic: exploring when and why they result in healthy pregnancies. Fertility and Sterility, 111 (2). pp. 280-293. ISSN 0015-0282. (doi:10.1016/j.fertnstert.2018.10.019) (KAR id:72238)
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| Official URL https://doi.org/10.1016/j.fertnstert.2018.10.019 |
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Abstract
Objective
Prospective study.
Setting
Fifty-nine patients.
Intervention(s)
Chemical start of pregnancy, implantation, fetal heartbeat, and birth.
Result(s)
After euploid embryos, mosaic embryos can be considered for transfer, prioritizing those of the single segmental mosaic type. If a patient has mosaic embryos available that were generated at different ages, preference should be given to those made at younger ages. Intrablastocyst karyotype discordance and differential cell proliferation and death might be reasons that embryos classified as mosaic can result in healthy pregnancies and babies.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1016/j.fertnstert.2018.10.019 |
| Uncontrolled keywords: | Mosaic, PGT-A, blastocyst, aneuploidy, next-generation sequencing |
| Divisions: | Faculties > Sciences > School of Biosciences |
| Depositing User: | Darren Griffin |
| Date Deposited: | 07 Feb 2019 11:20 UTC |
| Last Modified: | 25 Jan 2020 00:00 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/72238 (The current URI for this page, for reference purposes) |
| Griffin, Darren K.: |  https://orcid.org/0000-0001-7595-3226 |
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