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The Effect of Anodal Transcranial Direct Current Stimulation Over Left and Right Temporal Cortex on the Cardiovascular Response: A Comparative Study

Angius, Luca, Marcora, Samuele M., Hopker, James G., Mauger, Alexis R. (2018) The Effect of Anodal Transcranial Direct Current Stimulation Over Left and Right Temporal Cortex on the Cardiovascular Response: A Comparative Study. Frontiers in Physiology, 9 . Article Number 1822. ISSN 1664-042X. (doi:10.3389/fphys.2018.01822) (KAR id:72112)

Abstract

Background: Stimulation of the right and left anterior insular cortex, increases and decreases the cardiovascular response respectively, thus indicating the brain’s lateralization of the neural control of circulation. Previous experiments have demonstrated that transcranial direct current stimulation (tDCS) modulates the autonomic cardiovascular control when applied over the temporal cortex. Given the importance of neural control for a normal hemodynamic response, and the potential for the use of tDCS in the treatment of cardiovascular diseases, this study investigated whether tDCS was capable of modulating autonomic regulation.

Methods: Cardiovascular response was monitored during a post-exercise muscle ischemia (PEMI) test, which is well-documented to increase sympathetic drive. A group of 12 healthy participants performed a PEMI test in a control (Control), sham (Sham) and two different experimental sessions where the anodal electrode was applied over the left temporal cortex and right temporal cortex with the cathodal electrode placed over the contralateral supraorbital area. Stimulation lasted 20 min at 2 mA. The hemodynamic profile was measured during a PEMI test. The cardiovascular parameters were continuously measured with a transthoracic bio-impedance device both during the PEMI test and during tDCS.

Results: None of the subjects presented any side effects during or after tDCS stimulation. A consistent cardiovascular response during PEMI test was observed in all conditions. Statistical analysis did not find any significant interaction and any significant main effect of condition on cardiovascular parameters (all ps > 0.316) after tDCS. No statistical differences regarding the hemodynamic responses were found between conditions and time during tDCS stimulation (p > 0.05).

Discussion: This is the first study comparing the cardiovascular response after tDCS stimulation of left and right TC both during exercise and at rest. The results of the current study suggest that anodal tDCS of the left and right TC does not affect functional cardiovascular response during exercise PEMI test and during tDCS. In light of the present and previous findings, the effect of tDCS on the cardiovascular response remains inconclusive.

Item Type: Article
DOI/Identification number: 10.3389/fphys.2018.01822
Uncontrolled keywords: tDCS, heart rate, cardiovascular, metaboreflex, cardiac output, autonomic nervous system
Divisions: Divisions > Division of Natural Sciences > Sport and Exercise Sciences
Depositing User: Lex Mauger
Date Deposited: 01 Feb 2019 13:41 UTC
Last Modified: 28 Jul 2022 22:09 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/72112 (The current URI for this page, for reference purposes)

University of Kent Author Information

Angius, Luca.

Creator's ORCID:
CReDIT Contributor Roles:

Marcora, Samuele M..

Creator's ORCID: https://orcid.org/0000-0002-1570-7936
CReDIT Contributor Roles:

Hopker, James G..

Creator's ORCID: https://orcid.org/0000-0002-4786-7037
CReDIT Contributor Roles:

Mauger, Alexis R..

Creator's ORCID: https://orcid.org/0000-0001-6685-5800
CReDIT Contributor Roles:
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