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Inhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair

Ma, Jianhui, Benitez, Jorge A, Li, Jie, Miki, Sunichiro, Ponte de Alberquerque, Claudio, Galatro, Thais, Orellana, Laura, Zanca, Ciro, Reed, Rachel, Boyer, Antonia, and others. (2019) Inhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair. Cancer Cell, . ISSN 1535-6108. (doi:10.1016/j.ccell.2019.01.020) (KAR id:72083)

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https://doi.org/10.1016/j.ccell.2019.01.020

Abstract

Ionizing radiation (IR) and chemotherapy are standard of care treatments for glioblastoma

therapeutic resistance. We identified a mechanism of such resistance mediated by

elevated and bound to chromatin through interaction with Ki-67 in response to IR treatment and

confers radiation sensitivity to tumors and extends survival in GBM preclinical models. Y240FPten

pY240-PTEN is a key mechanism of radiation resistance and is an actionable target for

improving radiotherapy efficacy.

Item Type: Article
DOI/Identification number: 10.1016/j.ccell.2019.01.020
Uncontrolled keywords: PTEN, tyrosine phosphorylation, FGFR2, GBM, ionizing radiation (IR), DNA damage
Subjects: Q Science
R Medicine
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Tim Fenton
Date Deposited: 04 Mar 2019 10:15 UTC
Last Modified: 27 Feb 2020 00:00 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/72083 (The current URI for this page, for reference purposes)
Fenton, TR: https://orcid.org/0000-0002-4737-8233
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