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PEG conjugated citrate-capped magnetite nanoparticles for biomedical applications

Cheraghipour, E., Tamaddon, A.M., Javadpour, S., Bruce, Ian J. (2013) PEG conjugated citrate-capped magnetite nanoparticles for biomedical applications. Journal of Magnetism and Magnetic Materials, 328 . pp. 91-95. ISSN 0304-8853. (doi:10.1016/j.jmmm.2012.09.042) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1016/j.jmmm.2012.09.042

Abstract

We aim to develop polyethylene glycol decorated, citric acid capped magnetite nanoparticles (MNPs) with proper physicochemical characteristics including particle size distribution, morphology, magnetic property and stability in a biologic medium. MNP of about 10 nm were synthesized by a biocompatible chemical co-precipitation of Fe2+ and Fe3+ in an ammonia solution. A synthetic methodology has been developed to get a well dispersed and homogeneous aqueous suspension of MNPs. The naked MNPs are often insufficient for their stability, hydrophilicity and further functionalization. In order to overcome these limitations, citric acid was used to stabilize the magnetite particle suspension, which was anchored on the surface of freshly prepared MNPs by a direct addition method. Polyethylene glycol was covalently attached to the carboxylic moieties of citric acid anchored MNPs by carbodiimide chemistry. The microstructure and morphology of the nanoparticles were characterized by X-ray diffraction and transmission electron microscopy, and Fourier transform infrared spectroscopy. Also, the magnetic properties were investigated by vibrating sample magnetometry. It was found that the nanoparticles demonstrated superparamagnetic behavior.

Item Type: Article
DOI/Identification number: 10.1016/j.jmmm.2012.09.042
Uncontrolled keywords: Addition method; Ammonia solution; Aqueous suspensions; Biomedical applications; Carbodiimide chemistry; Chemical co-precipitation; Functionalizations; Magnetite particles; Physicochemical characteristics; Superparamagnetic behavior; Synthetic methodology; Vibrating sample magnetometry; Well-dispersed, Fourier transform infrared spectroscopy; Magnetic properties; Magnetite nanoparticles; Medical applications; Morphology; Nanoparticles; Particle size analysis; Polyethylene glycols; Precipitation (chemical); Superparamagnetism; Suspensions (fluids); Transmission electron microscopy; X ray diffraction, Citric acid
Subjects: Q Science
Q Science > QD Chemistry
Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Divisions: Faculties > Sciences > School of Physical Sciences
Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: I. Bruce
Date Deposited: 01 Feb 2019 16:31 UTC
Last Modified: 30 May 2019 08:49 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/71929 (The current URI for this page, for reference purposes)
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