Milne, BF, Morris, LA, Jaspars, Marcel, Thompson, GS (2002) Conformational change in the thiazole and oxazoline containing cyclic octapeptides, the patellamides. Part 2. Solvent dependent conformational change. Journal of the Chemical Society, Perkin Transactions 2, . pp. 1076-1080. ISSN 1472-779X. (doi:10.1039/b201824c) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:71823)
| The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
| Official URL: http://dx.doi.org/10.1039/b201824c |
Abstract
Solvent dependent conformational change of the thiazole and oxazoline containing cyclic peptides, the patellamides, is examined by a combination of experimental and theoretical methods. A mechanism for the simultaneous formation of two type-II ?-turns in the patellamides is proposed based on molecular dynamics and NOE restrained molecular dynamics studies as well as literature evidence. The effect of the solvent and desymmetrisation of the patellamides is crucial, with symmetrical patellamides in polar solvents giving the open type-I conformation, whereas symmetrical patellamides in non-polar solvents and asymmetrical patellamides in both polar and non-polar solvents give rise to the folded type-II conformation.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1039/b201824c |
| Subjects: | Q Science > QP Physiology (Living systems) > QP517 Biochemistry |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Gary Thompson |
| Date Deposited: | 23 Jan 2019 17:28 UTC |
| Last Modified: | 16 Nov 2021 10:26 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/71823 (The current URI for this page, for reference purposes) |
University of Kent Author Information
Thompson, GS.
| Creator's ORCID: |
 https://orcid.org/0000-0001-9399-7636
|
|---|---|
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