Singchat, Worapong, O’Connor, Rebecca, Tawichasri, Panupong, Suntronpong, Aorarat, Sillapaprayoon, Siwapech, Suntrarachun, Sunutcha, Muangmai, Narongrit, Baicharoen, Sudarath, Peyachoknagul, Surin, Chanhome, Lawan, and others. (2018) Chromosome map of the Siamese cobra: did partial synteny of sex chromosomes in the amniote represent “a hypothetical ancestral super-sex chromosome” or random distribution? BMC Genomics, 19 . Article Number 939. ISSN 1471-2164. (doi:10.1186/s12864-018-5293-6) (KAR id:71533)
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Official URL https://doi.org/10.1186/s12864-018-5293-6 |
Abstract
Background
We produced a detailed chromosome map of the Siamese cobra genome, focusing on chromosome 2 and sex chromosomes. Synteny of the Siamese cobra chromosome 2 (NKA2) and NKAZ were highly conserved among snakes and other squamate reptiles, except for intrachromosomal rearrangements occurring in NKA2. Interestingly, twelve BACs that had partial homology with sex chromosomes of several amniotes were mapped on the heterochromatic NKAW as hybridization signals such as repeat sequences. Sequence analysis showed that most of these BACs contained high proportions of transposable elements. In addition, hybridization signals of telomeric repeat (TTAGGG)n and six microsatellite repeat motifs ((AAGG)8, (AGAT)8, (AAAC)8, (ACAG)8, (AATC)8, and (AAAAT)6) were observed on NKAW, and most of these were also found on other amniote sex chromosomes.
Conclusions
The frequent amplification of repeats might involve heterochromatinization and promote sex chromosome differentiation in the Siamese cobra W sex chromosome. Repeat sequences are also shared among amniote sex chromosomes, which supports the hypothesis of an ancestral super-sex chromosome with overlaps of partial syntenies. Alternatively, amplification of microsatellite repeat motifs could have occurred independently in each lineage, representing convergent sex chromosomal differentiation among amniote sex chromosomes.
Item Type: | Article |
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DOI/Identification number: | 10.1186/s12864-018-5293-6 |
Uncontrolled keywords: | amniote, synteny, repeat sequences, sex chromosome, snake |
Subjects: | Q Science > QR Microbiology |
Divisions: | Divisions > Division of Natural Sciences > School of Biosciences |
Depositing User: | Darren Griffin |
Date Deposited: | 04 Jan 2019 10:19 UTC |
Last Modified: | 06 Oct 2020 19:34 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/71533 (The current URI for this page, for reference purposes) |
O’Connor, Rebecca: | ![]() |
Griffin, Darren K.: | ![]() |
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