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Past and future trends of Cryptosporidium in vitro research

Bones, Alexander J., Jossé, Lyne, More, Charlotte, Miller, Christopher N., Michaelis, Martin, Tsaousis, Anastasios D. (2019) Past and future trends of Cryptosporidium in vitro research. Experimental Parasitology, 196 . pp. 28-37. ISSN 0014-4894. (doi:10.1016/j.exppara.2018.12.001) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Abstract

Cryptosporidium is a genus of single celled parasites capable of infecting a wide range of animals including humans. Cryptosporidium species are members of the phylum apicomplexa, which includes well-known genera such as Plasmodium and Toxoplasma. Cryptosporidium parasites cause a severe gastro-intestinal disease known as cryptosporidiosis. They are one of the most common causes of childhood diarrhoea worldwide, and infection can have prolonged detrimental effects on the development of children, but also can be life threatening to HIV/AIDS patients and transplant recipients. A variety of hosts can act as reservoirs, and Cryptosporidium can persist in the environment for prolonged times as oocysts. While there has been substantial interest in these parasites, there is very little progress in terms of treatment development and understanding the majority of the life cycle of this unusual organism. In this review, we will provide an overview on the existing knowledge of the biology of the parasite and the current progress in developing in vitro cultivation systems. We will then describe a synopsis of current and next generation approaches that could spearhead further research in combating the parasite.

Item Type: Article
DOI/Identification number: 10.1016/j.exppara.2018.12.001
Additional information: Unmapped bibliographic data: DA - 2018/12/03/ [EPrints field already has value set] JO - Experimental Parasitology [Field not mapped to EPrints]
Subjects: Q Science > QR Microbiology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Anastasios Tsaousis
Date Deposited: 04 Dec 2018 09:49 UTC
Last Modified: 23 Aug 2019 13:49 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/70596 (The current URI for this page, for reference purposes)
Michaelis, Martin: https://orcid.org/0000-0002-5710-5888
Tsaousis, Anastasios D.: https://orcid.org/0000-0002-5424-1905
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