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Evidence of functional deficits at the single muscle fiber level in experimentally-induced renal insufficiency

Mitrou, Georgia I., Sakkas, Giorgos K., Poulianiti, Konstantina P., Karioti, Aggeliki, Tepetes, Konstantinos, Christodoulidis, Grigorios, Giakas, Giannis, Stefanidis, Ioannis, Geeves, Michael A., Koutedakis, Yiannis, and others. (2019) Evidence of functional deficits at the single muscle fiber level in experimentally-induced renal insufficiency. Journal of Biomechanics, 82 . pp. 259-265. ISSN 0021-9290. E-ISSN 1873-2380. (doi:10.1016/j.jbiomech.2018.10.035)

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Abstract

Chronic kidney disease patients present with metabolic and functional muscle

elucidated. We investigated whether chronic renal insufficiency (CRI) affects skeletal

Zealand rabbits (UREM), with sham-operation for controls (CON), and samples were

Ethics approval following national and European guidelines. Sample treatments and

psoas fibers (CON, n=142, UREM, n=240) initially at pH7, 10oC (‘standard’

physiological temperature (pH7, 30oC and pH6.2, 30oC). CRI resulted in significant

standard conditions, UREM fibers produced lower absolute and specific forces (i.e.

groups (P<0.01), but the disparity between UREM and CON remained significant.

(in UREM by -48% and in CON by -43%, P>0.05). For the first time, we give

force generation, only partially explained by fiber atrophy, thus affecting muscle

mechanics at the cellular level.

Item Type: Article
DOI/Identification number: 10.1016/j.jbiomech.2018.10.035
Uncontrolled keywords: Chronic kidney disease, isometric tension, skinned fibers, specific force, animal model, uremic myopathy
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Michael Geeves
Date Deposited: 03 Dec 2018 16:46 UTC
Last Modified: 03 Nov 2019 00:00 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/70584 (The current URI for this page, for reference purposes)
Geeves, Michael A.: https://orcid.org/0000-0002-9364-8898
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