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Investigations on the Mitochondrial Protein Composition of Microbial Eukaryotes from Diverse Physical Environments

Williams, Luke (2017) Investigations on the Mitochondrial Protein Composition of Microbial Eukaryotes from Diverse Physical Environments. Master of Philosophy (MPhil) thesis, University of Kent,. (KAR id:70177)

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Abstract

Ciliates are a group of microbial eukaryotes that are found in diverse environments, which have been identified to contain different classes of mitochondria. It is understood that mitochondria have modified their functions overtime depending on the environment of their host; these differences in adaptations allow mitochondria to be classified into five different groups/classes. Four of these classes generate adenosine triphosphate (ATP), while the fifth has undergone evolutionary reduction having no apparent role in ATP synthesis. The aim of this project was to evaluate the diversity of these organelles in ciliates. This was carried out using computational methods, where we analysed and translated genomic and transcriptomic data collected from 27 ciliates found in diverse environments. The ciliate data were searched against a database of nine different mitochondrial proteomes and multiple anaerobically functioning proteins in order to assemble the potential mitochondrial proteome for each organism based on sequence similarity.

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This diversity of mitochondrial class seen throughout the ciliate clade further supports the claim of anaerobically functioning mitochondria potentially being the ancestral mitochondria of ciliates.

Item Type: Thesis (Master of Philosophy (MPhil))
Thesis advisor: Tsaousis, Anastasios
Thesis advisor: Wass, Mark
Uncontrolled keywords: mitochondria, evolution, diversity, mitochondrial related organelles, ciliates
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
SWORD Depositor: System Moodle
Depositing User: System Moodle
Date Deposited: 19 Nov 2018 10:11 UTC
Last Modified: 22 Jan 2020 04:11 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/70177 (The current URI for this page, for reference purposes)
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