Skip to main content

High Viral Diversity and Mixed Infections in Cerebral Spinal Fluid From Cases of Varicella Zoster Virus Encephalitis

Depledge, Daniel P, Cudini, Juliana, Kundu, Samit, Atkinson, Claire, Brown, Julianne R, Haque, Tanzina, Houldcroft, Charlotte J, Koay, Evelyn S, McGill, Fiona, Milne, Richard, and others. (2018) High Viral Diversity and Mixed Infections in Cerebral Spinal Fluid From Cases of Varicella Zoster Virus Encephalitis. The Journal of Infectious Diseases, 218 (10). pp. 1592-1601. ISSN 0022-1899. (doi:10.1093/infdis/jiy358) (KAR id:69866)

PDF Publisher pdf
Language: English


Creative Commons Licence
This work is licensed under a Creative Commons Attribution 4.0 International License.
Download (3MB) Preview
[img]
Preview
Official URL
https://doi.org/10.1093/infdis/jiy358

Abstract

Background

Enrichment-based deep sequencing of 45 VZV genomes from cerebral spinal fluid (CSF), plasma, bronchoalveolar lavage (BAL), and vesicles was carried out with samples collected from 34 patients with and without VZV infection of the CNS.

Results

Low viral genetic diversity in vesicle fluid is compatible with previous observations that VZV skin lesions arise from single or low numbers of virions. A similar result was observed in VZV from cases of VZV meningitis, a generally self-limiting infection. CSF from cases of encephalitis had higher diversity with evidence for mixed clade infections in 2 cases. We hypothesize that reactivation from multiple neurons may contribute to the pathogenesis of VZV encephalitis.

Item Type: Article
DOI/Identification number: 10.1093/infdis/jiy358
Uncontrolled keywords: varicella zoster virus, encephalitis, viral population, evolution, neurotropism, pathogenesis
Subjects: Q Science > QR Microbiology
Divisions: Faculties > Social Sciences > School of Anthropology and Conservation
Depositing User: Samit Kundu
Date Deposited: 31 Oct 2018 16:29 UTC
Last Modified: 29 May 2019 21:22 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/69866 (The current URI for this page, for reference purposes)
  • Depositors only (login required):

Downloads

Downloads per month over past year