Papakrivopoulou, Eugenia, Vasilopoulou, Elisavet, Lindenmeyer, Maja T, Pacheco, Sabrina, Brzóska, Hortensja ?, Price, Karen L, Kolatsi-Joannou, Maria, White, Kathryn E, Henderson, Deborah J, Dean, Charlotte H, and others. (2018) Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury. Journal of Pathology, 246 (4). pp. 485-496. ISSN 0022-3417. (doi:10.1002/path.5158) (KAR id:69815)
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| Official URL https://doi.org/10.1002/path.5158 |
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Abstract
Planar cell polarity (PCP) pathways control the orientation and alignment of epithelial cells
differentiation of kidney glomeruli and tubules. Vangl2 has also been implicated in
Vangl2 impacts on glomerular pathobiology in this context. Targeted genetic deletion of
irreversible accelerated nephrotoxic nephritis but also lipopolysaccharide-induced
podocytes was associated with an increased ratio of active-MMP9 to inactive MMP9, an
two cohorts of renal patients, we report increased VANGL2 transcript levels in glomeruli of
be involved in certain human glomerular diseases. These observations support the
MMP9, a potentially harmful endogenous enzyme.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1002/path.5158 |
| Uncontrolled keywords: | glomerulus, kidney disease, matrix metalloproteinase, planar cell polarity, podocyte |
| Subjects: |
Q Science > QR Microbiology R Medicine |
| Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
| Depositing User: | Elisavet Vasilopoulou |
| Date Deposited: | 27 Oct 2018 15:36 UTC |
| Last Modified: | 16 Feb 2021 13:58 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/69815 (The current URI for this page, for reference purposes) |
| Vasilopoulou, Elisavet: |  https://orcid.org/0000-0002-1940-0333 |
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