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Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury

Papakrivopoulou, Eugenia, Vasilopoulou, Elisavet, Lindenmeyer, Maja T, Pacheco, Sabrina, Brzóska, Hortensja ?, Price, Karen L, Kolatsi-Joannou, Maria, White, Kathryn E, Henderson, Deborah J, Dean, Charlotte H, and others. (2018) Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury. Journal of Pathology, . ISSN 0022-3417. (doi:10.1002/path.5158) (KAR id:69815)

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https://doi.org/10.1002/path.5158

Abstract

Planar cell polarity (PCP) pathways control the orientation and alignment of epithelial cells

differentiation of kidney glomeruli and tubules. Vangl2 has also been implicated in

Vangl2 impacts on glomerular pathobiology in this context. Targeted genetic deletion of

irreversible accelerated nephrotoxic nephritis but also lipopolysaccharide-induced

podocytes was associated with an increased ratio of active-MMP9 to inactive MMP9, an

two cohorts of renal patients, we report increased VANGL2 transcript levels in glomeruli of

be involved in certain human glomerular diseases. These observations support the

MMP9, a potentially harmful endogenous enzyme.

Item Type: Article
DOI/Identification number: 10.1002/path.5158
Uncontrolled keywords: glomerulus, kidney disease, matrix metalloproteinase, planar cell polarity, podocyte
Subjects: Q Science > QR Microbiology
R Medicine
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Elisavet Vasilopoulou
Date Deposited: 27 Oct 2018 15:36 UTC
Last Modified: 29 May 2019 21:21 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/69815 (The current URI for this page, for reference purposes)
Vasilopoulou, Elisavet: https://orcid.org/0000-0002-1940-0333
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